Effects of Dermatan Sulfate, a Heparin Cofactor II Mediated Thrombin Inhibitor, on the Endotoxin-Induced Disseminated Intravascular Coagulation Model in the Rat: Comparison With Low-Molecular Weight Heparin, Nafamostat Mesilate and Argathroban
| Autor: | Atsuko Sunose, Junichi Onaya, Mamoru Kyogashima, Satoshi Miyauchi, Syoji Mizuno, Katsuyuki Horie |
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| Rok vydání: | 1998 |
| Předmět: |
Male
medicine.drug_class Dermatan Sulfate Low molecular weight heparin Pharmacology Arginine Fibrinogen Guanidines Dermatan sulfate Fibrin Rats Sprague-Dawley chemistry.chemical_compound Thrombin medicine Animals Disseminated intravascular coagulation Heparin cofactor II Sulfonamides biology Heparin Disseminated Intravascular Coagulation medicine.disease Benzamidines Rats Endotoxins Molecular Weight Disease Models Animal chemistry Pipecolic Acids Immunology Heparin Cofactor II biology.protein medicine.drug |
| Zdroj: | Japanese Journal of Pharmacology. 76:397-404 |
| ISSN: | 0021-5198 |
| Popis: | Effects of dermatan sulfate (DS) on the endotoxin-induced disseminated intravascular coagulation (DIC) rat model were compared with those of low-molecular weight heparin (LMWH), nafamostat mesilate (NM) and argathroban (AR). At doses of 5, 10 or 20 mg/kg/4 hr, DS significantly ameliorated the decrease of fibrinogen (Fbg), the increase of fibrin-fibrinogen degradation products (FDP) and except at the highest dose (20 mg/kg/4 hr), the prolongation of thrombin clotting time (TCT). It also decreased the glomerular fibrin deposits (%GFD) at doses of 10 or 20 mg/kg/4 hr. LMWH suppressed the decrease of Fbg and the increase of FDP at doses of 1.4 or 2.8 mg/kg/4 hr. Only the highest dose of LMWH suppressed the decrease of the platelet count (PL), the prolongation of prothrombin time, and improved the %GFD. AR suppressed the decrease of PL and improved the %GFD. At the dose required to improve the %GFD, DS (5, 10 mg/kg/4 hr) significantly suppressed the prolongation of TCT, which is related to the bleeding frequency, while LMWH and AR further increased the prolongation of the TCT. These results suggest that DS has potential as a therapeutic drug with a lower hemorrhagic risk as compared with LMWH and AR in the treatment of DIC. |
| Databáze: | OpenAIRE |
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