Phase-I trial of intravenous continuous infusion of tumor necrosis factor in advanced metastatic carcinomas

Autor: Werner Hunstein, U. Räth, Bertram Wiedenmann, Erich Schlick, Peter Reichardt, Birgit Schüle, Joachim Kempeni, Anthony D. Ho, Burkhard Kommerell, Lorenz Theilmann
Rok vydání: 1989
Předmět:
Zdroj: Journal of Cancer Research and Clinical Oncology. 115:189-192
ISSN: 1432-1335
0171-5216
DOI: 10.1007/bf00397922
Popis: Fifteen patients with advanced metastatic adenocarcinomas were treated in a phase-I study with continuous intravenous 24 h infusion of recombinant tumor necrosis factor alpha (TNF-alpha) in order to determine the maximum tolerated dose (MTD) and associated side-effects. Patients received 40-400 micrograms/m2 TNF-alpha once (arm A) or twice (arm B) weekly for a scheduled treatment period of 2 months. The observed systemic side-effects resembled those reported for interferons and included fever, chills, fatigue, headaches, myalgias, thrombocytopenia, prostration, and malaise. Dose-limiting toxicities, resulting in a median MTD of 200 micrograms/m2 for 24 h, were fever, chills, fatigue, myalgias, and thrombocytopenia. Out of 15 patients, 11 showed tumor progression, and 3 sustained in no change for over 2 months of treatment. A minor response was seen in 1 patient with a colorectal carcinoma and liver metastases. To reduce side-effects, patients were treated either with paracetamol or indomethacin. Higher MTDs were observed in patients treated with indomethacin. No detectable plasma TNF-alpha levels or TNF antibodies were measured under therapy (plasma TNF-alpha less than 20 pg/ml). We conclude that TNF-alpha appears to have some antineoplastic activity in patients with adenocarcinomas since 4 patients remained in no change or showed a minor response.
Databáze: OpenAIRE
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