Novel heteroaryl replacements of aromatic 3-tetrafluoroethoxy substituents in trifluoro-3-(tertiaryamino)-2-propanols as potent inhibitors of cholesteryl ester transfer protein

Autor:	Brian S. Hickory, Richard C. Durley, James A. Sikorski, Mark A. Massa, Mark E. Smith, Bryan J. Witherbee, Dale P. Spangler, Daniel T. Connolly
Rok vydání:	2001
Předmět:	biology Tertiary amine Stereochemistry Chemistry Propanols Organic Chemistry Clinical Biochemistry Pharmaceutical Science Haloalcohol Biochemistry Chemical synthesis In vitro Cholesterol Ester Transfer Proteins Carrier protein Drug Discovery Cholesterylester transfer protein Benzene derivatives biology.protein Molecular Medicine Molecule lipids (amino acids peptides and proteins) Carrier Proteins Molecular Biology Glycoproteins
Zdroj:	Bioorganicmedicinal chemistry letters. 11(13)
ISSN:	0960-894X
Popis:	A series of novel N,N-disubstituted trifluoro-3-amino-2-propanols has been prepared as potent inhibitors of cholesteryl ester transfer protein (CETP). Modifying the aromatic 3-tetrafluoroethoxy group in the lead molecule 1a with various heteroaryl moieties produced new 2-furyl analogues 2a,b with submicromolar potency in vitro.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cec2ae537b038bd8e7cd5a16dad966f https://pubmed.ncbi.nlm.nih.gov/11425523 Zobrazit plný text záznamu Full Text from ScienceDirect