Effects of tissue disorganization on proteoglycan synthesis by articular chondrocytes in vitro
| Autor: | Rj Vandestadt, Hs Brand, E Kiljan, Roelof Kuijer, Gpj Vankampen, Jk Vanderkorst |
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| Rok vydání: | 1988 |
| Předmět: |
Pharmacology
Cartilage Articular Chemistry Cartilage Immunology Chondroitin Sulfates High density Articular cartilage Toxicology In vitro Cell biology carbohydrates (lipids) medicine.anatomical_structure Chondroitin sulphate Sulfation medicine Proteoglycan synthesis Animals Pharmacology (medical) Cattle Proteoglycans Cells Cultured Explant culture |
| Zdroj: | Agents and actions. 23(1-2) |
| ISSN: | 0065-4299 |
| Popis: | In response to degenerative changes (tissue disorganization) in articular cartilage, chondrocytes synthesize proteoglycans which differ in several aspects from those found in healthy cartilage [1]. The main object of this study was to investigate the effects of the severity of tissue disorganization on the nature of the newly synthezised proteoglycans. The proteoglycans synthesized by chondrocytes in explant cultures, high density (pellet) and monolayer cultures are compared. The study is focussed on the degree of sulphation and the position of sulphate in chondroitin sulphate chains ofproteoglycans synthesized in vitro. |
| Databáze: | OpenAIRE |
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