Secretion by glucagonomas of a possible glucagon precursor
| Autor: | David M. Slovik, T T Aoki, Edward S. Horton, Gordon C. Weir, Jonathan B. Jaspan, Arthur H. Rubenstein |
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| Rok vydání: | 1977 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty Prohormone Alpha (ethology) Biology Glucagon Alpha cell Antigen-Antibody Reactions Antigen Internal medicine medicine Humans Secretion Protein Precursors Beta (finance) medicine.diagnostic_test General Medicine Middle Aged Molecular Weight Pancreatic Neoplasms Endocrinology Immunoassay Female hormones hormone substitutes and hormone antagonists Research Article medicine.drug |
| Zdroj: | Journal of Clinical Investigation. 59:325-330 |
| ISSN: | 0021-9738 |
| DOI: | 10.1172/jci108644 |
| Popis: | Five patients with glucagonomas had elevated plasma levels of total glucagon immunoreactivity. Gel filtrations of these plasma samples on Bio-Gel P30 columns showed that most of the immunoreactivity eluted in the 3,500-(true glucagon) and 9,000-dalton fractions. After the administration of alpha cell effectors, changes in total glucagon immunoreactivity were seen which were accounted for primarily by the 3,500-dalton species, but there were also changes in the 9,000-dalton moiety. Venous effluent plasma from tumors of two subjects contained elevated concentrations of glucagon immunoreactivity in both fractions. When material from both the 3,500- and 9,000-dalton peaks were serially diluted in a glucagon immunoassay, parallel displacement curves were found, suggesting that both have similar or identical antigenic determinants. Thus, with conversion to a neoplastic state, alpha cells of glucagonomas, much like beta cells of insulinomas, may secrete an increased amount of a larger, 9,000-mol wt glucagon species which may be a prohormone. |
| Databáze: | OpenAIRE |
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