Development of a New 3D Hybrid Model for Epithelia Morphogenesis
| Autor: | Filippos Ioannou, Malik A. Dawi, Robert J. Tetley, Yanlan Mao, José J. Muñoz |
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| Přispěvatelé: | Universitat Politècnica de Catalunya. Departament de Matemàtiques, Universitat Politècnica de Catalunya. LACÀN - Mètodes Numèrics en Ciències Aplicades i Enginyeria |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Histology Càlculs numèrics lcsh:Biotechnology Biomedical Engineering Morphogenesis morphogenesis Bioengineering wound healing 02 engineering and technology Biotecnologia 03 medical and health sciences lcsh:TP248.13-248.65 Bioenginyeria vertex Collective dynamics Original Research Physics Matemàtiques i estadística [Àrees temàtiques de la UPC] Bioengineering and Biotechnology Cell migration modeling Numerical calculations Cell sorting Tissue repair 021001 nanoscience & nanotechnology 030104 developmental biology Biophysics Wound closure 0210 nano-technology Hybrid model three dimensions Biotechnology |
| Zdroj: | Frontiers in Bioengineering and Biotechnology Frontiers in Bioengineering and Biotechnology, Vol 8 (2020) UPCommons. Portal del coneixement obert de la UPC Universitat Politècnica de Catalunya (UPC) |
| ISSN: | 2296-4185 |
| Popis: | Many epithelial developmental processes like cell migration and spreading, cell sorting, or T1 transitions can be described as planar deformations. As such, they can be studied using two-dimensional tools and vertex models that can properly predict collective dynamics. However, many other epithelial shape changes are characterized by out-of-plane mechanics and three-dimensional effects, such as bending, cell extrusion, delamination, or invagination. Furthermore, during planar cell dynamics or tissue repair in monolayers, spatial intercalation between the apical and basal sides has even been detected. Motivated by this lack of symmetry with respect to the midsurface, we here present a 3D hybrid model that allows us to model differential contractility at the apical, basal or lateral sides. We use the model to study the effects on wound closure of solely apical or lateral contractile contributions and show that an apical purse-string can be sufficient for full closure when it is accompanied by volume preservation. |
| Databáze: | OpenAIRE |
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