Feasibility of Pulmonary Ventilation Visualization With Aerosolized Magnetic Resonance Contrast Media
| Autor: | E. Spüntrup, Huu Tri Truong, Patrick Haage, Rolf W. Günther, Süleyman Karaagac, Thorsten Schmidt |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Adult
Gadolinium DTPA Pathology medicine.medical_specialty Gadolinium media_common.quotation_subject chemistry.chemical_element medicine Humans Contrast (vision) Radiology Nuclear Medicine and imaging Respiratory system Lung Aerosolization media_common Aerosols medicine.diagnostic_test business.industry Magnetic resonance imaging Imaging Procedures General Medicine Middle Aged respiratory system Magnetic Resonance Imaging chemistry Lung disease Breathing Feasibility Studies business Biomedical engineering |
| Zdroj: | Investigative Radiology. 40:85-88 |
| ISSN: | 0020-9996 |
| Popis: | Objective: The objective of this study was to evaluate a new approach to noninvasive magnetic resonance assessment of human pulmonary ventilation with aerosolized Gd-DTPA. Materials and Methods: Fifteen experimental procedures were carried out in 15 healthy volunteers on a 1.5-T imager. For a timespan of 10 minutes, the subjects spontaneously inhaled a commercially available Gd-DTPA magnetic resonance contrast agent in aerosolized form through an inflatable facemask. Gd-DTPA was aerosolized by means of a small-particle generator with integrated heater to increase aerosol production. Respiratory gated dynamic Tl-weighted turbo spin echo images were obtained before and after contrast agent aerosol administration. After nebulization, homogeneity of aerosol distribution was graded by 2 experienced readers and pulmonary signal intensity (SI) changes were measured in corresponding regions of both lungs. Results: Pulmonary ventilation visualization, and hence contrast agent delivery, was rated homogeneously distributed by both readers in 14 of 15 cases (93.3%) and slightly inhomogeneous in 1 case (6.7%). Pulmonary SI increased by an average of +37% ′ 8.5 (range, 10-48%). Allergic responses were not noted. Conclusions: Human ventilation imaging with aerosolized gadolinium-chelates is viable. The presented modality might evolve as an alternative to current nuclear medicine and magnetic resonance image ventilation imaging procedures, avoiding radiation exposure while offering functional ventilation assessment with an acceptable temporal and spatial resolution. Nevertheless, further evaluation is required to define the potential of gadolinium-based ventilation magnetic resonance imaging in illustrating lung disease. |
| Databáze: | OpenAIRE |
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