Can mesenchymal stem cells ameliorate testicular damage? Current researches
| Autor: | Büşra Çetinkaya Ün, Meryem Akpolat Ferah, Burak Ün |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Infertility
Medicine (General) endocrine system RD1-811 medicine.medical_treatment azospermi mezenkimal kök hücreler urologic and male genital diseases stem cell therapy male infertility Male infertility Paracrine signalling testicular damage R5-920 kök hücre tedavisi medicine Testicular torsion Azoospermia mesenchymal stem cells Chemotherapy business.industry azoospermia Mesenchymal stem cell Stem-cell therapy medicine.disease erkek infertilitesi Cancer research Medicine Surgery business testis hasarı |
| Zdroj: | Journal of Surgery and Medicine, Vol 4, Iss 7, Pp 603-607 (2020) |
| ISSN: | 2602-2079 |
| DOI: | 10.28982/josam.770063 |
| Popis: | Many recent studies have demonstrated the therapeutic effects of mesenchymal stem cells (MSC) in different disease models. Infertility is a global disease with a high prevalence. Non-obstructive azoospermia may occur due to genetic factors, exposure to toxic substances, anticancer treatments such as radiotherapy and chemotherapy and testicular torsion. Many experiments have been conducted to determine the efficacy of MSCs in the treatment of male infertility due to their differentiation capacity and paracrine effect. In these studies, the differentiation capacities of MSCs, obtained from diverse sources, to male germ cells were determined in vitro and their effects on testis niche were assessed by injection of MSCs into the testis. In this review, we addressed a few of the causes of non-obstructive azoospermia and summarized the current studies to determine the therapeutic effects of MSCs on testicular injury. |
| Databáze: | OpenAIRE |
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