Constituents, Antibacterial Adhesion, Cytotoxic and in Vitro Metastasis Blocking Properties of Salvia fruticosa Essential Oils from Three Palestinian Localities

Autor:	Nidal Jaradat, Samer Abdallah, Nawaf Al‐Maharik, Mohammad Altamimi, Mohammed Hawash, Mohammad Qneibi, Abeer Abu Khair, Anaal Zetawi, Leena Jabarin
Rok vydání:	2022
Předmět:	Antineoplastic Agents Bioengineering Microbial Sensitivity Tests General Chemistry General Medicine Biochemistry Anti-Bacterial Agents Arabs Klebsiella pneumoniae Oils Volatile Humans Molecular Medicine Salvia Caco-2 Cells Molecular Biology
Zdroj:	Chemistry & Biodiversity. 19
ISSN:	1612-1880 1612-1872
Popis:	Essential oils (EOs) of Salvia fruticosa Mill. gathered from three Palestinian localities were studied to determine their constituents, antibacterial adhesion impact against Klebsiella pneumonia, cytotoxicity, and their function in cancer cell migration. Gas chromatography-mass spectrometry identified the chemical components, while the MTT technique was used to measure the EOs' cytotoxicity against HeLa (cervical) and Caco-2 (colorectal) cancer cells. Antibacterial adhesion was assessed by examining Klebsiella pneumoniae's ability to adhere to Caco-2 cells. Our study found that eucalyptol was present as the main constituent in all S. fruticosa EOs. In addition, K. pneumoniae adhesion and metastasis were reduced after 48 h of application. Salfit's and Hebron's EOs had the most potent cytotoxic effects on Caco-2 and HeLa, with IC
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ce4a18a6eb5cfca6ec65555aaaa3925 https://doi.org/10.1002/cbdv.202100872 Zobrazit plný text záznamu Plný text