Association of endogenous testosterone with subclinical atherosclerosis in men: the multi-ethnic study of atherosclerosis

Autor: Matthew J. Budoff, Kiang Liu, Dong Li, Laura A. Colangelo, Mary Cushman, Dhananjay Vaidya, Lily Honoris, Sherita Hill Golden, Adrian S. Dobs, Christina Wang, Peter Kopp, Pamela Ouyang, Bahram Khazai, Susan M. Gapstur, Ronald S. Swerdloff
Rok vydání: 2016
Předmět:
Male
medicine.medical_specialty
Endocrinology
Diabetes and Metabolism
Population
Dehydroepiandrosterone
030209 endocrinology & metabolism
030204 cardiovascular system & hematology
Carotid Intima-Media Thickness
Risk Assessment
White People
03 medical and health sciences
0302 clinical medicine
Endocrinology
Sex hormone-binding globulin
Risk Factors
Sex Hormone-Binding Globulin
Internal medicine
medicine
Humans
Testosterone
Prospective Studies
cardiovascular diseases
education
Prospective cohort study
Coronary atherosclerosis
Aged
Aged
80 and over
education.field_of_study
Asian
Estradiol
biology
business.industry
nutritional and metabolic diseases
Hispanic or Latino
Middle Aged
Atherosclerosis
Coronary Vessels
United States
Black or African American
Multivariate Analysis
Cohort
cardiovascular system
biology.protein
Calcium
business
Hormone
Zdroj: Clinical Endocrinology. 84:700-707
ISSN: 0300-0664
DOI: 10.1111/cen.12997
Popis: Objectives Whether endogenous sex hormones play a role in cardiovascular disease (CVD) risk in men is unclear. Few studies have examined associations of sex hormones with atherosclerosis measured by coronary artery calcium score (CACS) and carotid intima-media thickness (cIMT). We evaluated the association of testosterone (T) and other sex hormones with CACS and cIMT. Methods Using the large multi-ethnic cohort of 3164 men without known CVD in the Multi-Ethnic Study of Atherosclerosis (MESA), cross-sectional associations of tertiles of endogenous sex hormones with CACS and cIMT were analysed. Results In regard to CAC, there was a significant negative trend (P-trend = 0·02) for CACS>0 over tertiles of free T (FT) with RRs (95% CI) for the lowest to highest tertiles. There was also a marginally significant positive trend (P-trend = 0·06) for CACS>0 over tertiles of sex hormone-binding globulin (SHBG) with RRs for the lowest to highest tertiles. There were no significant associations with CACS >0 for tertiles of TT (Total T), bioavailable T (BT), oestradiol (E2) and dehydroepiandrosterone (DHEA). There was significantly higher log CACS after adjustment for CVD risk factors for lower TT levels, compared to higher levels, using 9·54 and 10·4 nmol/l as cut-off points. In regard to cIMT, there was a significant positive trend (P = 0·003) in mean cIMT over the tertiles of BT, but not for TT, FT, E2, DHEA and SHBG. There was significantly lower cIMT after adjustment for CVD risk factors for lower TT levels compared to higher levels. Conclusion In a population of male subjects with no known CVD, lower FT is associated with higher RR of CACS>0 and lower TT is associated with higher log CACS. Lower BT and TT are associated with lower cIMT. While these findings support the positive correlation between low T and coronary atherosclerosis, the opposite findings on cIMT warrant further evaluation.
Databáze: OpenAIRE
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