The renin-angiotensin-system and left ventricular mass in young adults: the African-PREDICT study
| Autor: | Catharina M. C. Mels, Aletta E. Schutte, Wessel L. Du Toit, Lebo F. Gafane-Matemane, Ruan Kruger |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Black People 030204 cardiovascular system & hematology Left ventricular hypertrophy Renin-Angiotensin System Left ventricular mass 03 medical and health sciences 0302 clinical medicine Internal medicine Renin Renin–angiotensin system Internal Medicine medicine Humans 030212 general & internal medicine Young adult Ventricular Remodeling business.industry Angiotensin II General Medicine medicine.disease Echocardiography Cardiology Female Hypertrophy Left Ventricular Raised blood pressure Angiotensin I Cardiology and Cardiovascular Medicine business |
| Zdroj: | Blood Pressure. 30:98-107 |
| ISSN: | 1651-1999 0803-7051 |
| DOI: | 10.1080/08037051.2020.1831902 |
| Popis: | Raised blood pressure, with the renin-angiotensin system (RAS) as a central regulatory component, is one of the most important contributors to early development of left ventricular hypertrophy. Factors such as increased age, sex, black ethnicity and a low socio-economic status also contribute to left ventricular remodelling. To better understand early contributors to left ventricular mass, we investigated the relationship between left ventricular mass index (LVMi) and the components of the RAS in young healthy adults while considering ethnicity, sex and socio-economic status.Black and white women and men (Components of the RAS such as plasma renin activity (PRA-S), angiotensin I (Ang I), angiotensin II (Ang II) and aldosterone were suppressed in the black compared to the white group (allDespite a suppressed RAS in the black compared to the white group, components of the RAS were not associated with LVMi in this young cohort. The low socio-economic black women of this study population may be vulnerable to future RAS-related increases in left ventricular mass. |
| Databáze: | OpenAIRE |
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