Comparison of echocardiographic measurements to invasive measurements of diastolic function in infants with single ventricle physiology: a report from the Pediatric Heart Network Infant Single Ventricle Trial
| Autor: | Jami C. Levine, Joshua Sticka, Mark K. Friedberg, Peter Shrader, Victor Zak, Karen Altmann, Christine B Falkensammer, Andrew M. Atz, Kevin D. Hill, Christopher R. Mart, Michele A. Frommelt, Steven D. Colan, Girish S Shirali, Suma Goudar, Daphne T. Hsu, Renee Margossian |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Heart Defects
Congenital Male medicine.medical_specialty Cardiac Catheterization Sedation Heart Ventricles Diastole 030204 cardiovascular system & hematology Article Ventricular Function Left 03 medical and health sciences 0302 clinical medicine Double-Blind Method Enalapril Internal medicine medicine Ventricular Pressure Humans Diastolic function 030212 general & internal medicine Antihypertensive Agents Retrospective Studies business.industry Infant Newborn Infant General Medicine Echocardiography Doppler medicine.anatomical_structure Sample size determination Single ventricle physiology Ventricle Pediatrics Perinatology and Child Health Cohort Cardiology Female medicine.symptom Cardiology and Cardiovascular Medicine business medicine.drug Follow-Up Studies |
| ISSN: | 1047-9511 |
| Popis: | Background:While echocardiographic parameters are used to quantify ventricular function in infants with single ventricle physiology, there are few data comparing these to invasive measurements. This study correlates echocardiographic measures of diastolic function with ventricular end-diastolic pressure in infants with single ventricle physiology prior to superior cavopulmonary anastomosis.Methods:Data from 173 patients enrolled in the Pediatric Heart Network Infant Single Ventricle enalapril trial were analysed. Those with mixed ventricular types (n = 17) and one outlier (end-diastolic pressure = 32 mmHg) were excluded from the analysis, leaving a total sample size of 155 patients. Echocardiographic measurements were correlated to end-diastolic pressure using Spearman’s test.Results:Median age at echocardiogram was 4.6 (range 2.5–7.4) months. Median ventricular end-diastolic pressure was 7 (range 3–19) mmHg. Median time difference between the echocardiogram and catheterisation was 0 days (range −35 to 59 days). Examining the entire cohort of 155 patients, no echocardiographic diastolic function variable correlated with ventricular end-diastolic pressure. When the analysis was limited to the 86 patients who had similar sedation for both studies, the systolic:diastolic duration ratio had a significant but weak negative correlation with end-diastolic pressure (r = −0.3, p = 0.004). The remaining echocardiographic variables did not correlate with ventricular end-diastolic pressure.Conclusion:In this cohort of infants with single ventricle physiology prior to superior cavopulmonary anastomosis, most conventional echocardiographic measures of diastolic function did not correlate with ventricular end-diastolic pressure at cardiac catheterisation. These limitations should be factored into the interpretation of quantitative echo data in this patient population. |
| Databáze: | OpenAIRE |
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