The effect of menopause on the innate antiviral activity of cervicovaginal lavage
| Autor: | Kevin Uranker, Charlene S. Dezzutti, Charles E. Isaacs, Catherine A. Chappell, Weimin Xu, Bernard J. Moncla, Leslie A. Meyn, Sharon L. Hillier |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Adult
medicine.medical_specialty media_common.quotation_subject Herpesvirus 2 Human Physiology HIV Infections Cervix Uteri Herpesvirus 1 Human Levonorgestrel Medroxyprogesterone Acetate Viral Plaque Assay Intrauterine device Asymptomatic Article Young Adult medicine Contraceptive Agents Female Medroxyprogesterone acetate Humans Young adult Menstrual cycle Menstrual Cycle media_common Gynecology business.industry Intrauterine Devices Medicated Obstetrics and Gynecology Herpes Simplex Middle Aged medicine.disease Immunity Innate Menopause Postmenopause Contraceptives Oral Combined medicine.anatomical_structure Premenopause Vagina HIV-1 Vaginal Douching Female Disease Susceptibility medicine.symptom business medicine.drug |
| Zdroj: | American journal of obstetrics and gynecology. 213(2) |
| ISSN: | 1097-6868 |
| Popis: | Reproductive hormones are known to impact innate mucosal immune function of the lower genital tract. Our objectives were to determine the effect of hormonal status on intrinsic antiviral (herpes simplex virus [HSV]-1, HSV-2, and human immunodeficiency virus [HIV]-1) activity of cervicovaginal lavage (CVL).CVL was collected from 165 asymptomatic women including postmenopausal women (n = 29); women not on contraception in days 1-14 (n = 26) or days 15-28 (n = 27) of the menstrual cycle; and women using the levonorgestrel intrauterine device (n = 28), depot medroxyprogesterone acetate (n = 28), or combined oral contraceptives (n = 27). The anti-HSV-1/-2 and the anti-HIV-1 activity of the CVL were measured using plaque assays and the Jurkat-Tat-CCR5 assay, respectively.CVL from all of the groups had modest antiviral activity. Anti-HIV-1 activity was decreased in CVL from postmenopausal women when compared to premenopausal women (11% vs 34%, P = .002). However, there was no difference in anti-HIV-1 activity among premenopausal women regardless of phase of menstrual cycle or contraceptive use. Anti-HIV-1 activity was associated with the protein content of the CVL (r = 0.44, P.001). There was no difference in anti-HSV-1 or -2 activity by hormonal group.Menopause is associated with decreased innate HIV-1 activity in the lower genital tract, suggesting that factors in the vaginal fluid could play a role in increased susceptibility of HIV-1 infection in postmenopausal women. Hormonal contraceptive use, menopause, and phase of menstrual cycle did not have a measurable impact on the intrinsic anti-HSV-1 or -2 activity. |
| Databáze: | OpenAIRE |
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