Renal Phosphate Handling in Antiretroviral-naive HIV-Infected Patients
| Autor: | Rotimi S. Owolabi, Simeon Adelani Adebisi, Nife Olamide Adedeji, Tewogbade Adeoye Adedeji, Olusola A. Jeje |
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| Rok vydání: | 2020 |
| Předmět: |
Microbiology (medical)
Male medicine.medical_specialty Anti-HIV Agents Human immunodeficiency virus (HIV) Renal function HIV Infections Urine medicine.disease_cause Kidney Gastroenterology Phosphates Excretion chemistry.chemical_compound Acquired immunodeficiency syndrome (AIDS) Internal medicine medicine Humans Pharmacology Creatinine business.industry General Medicine Odds ratio Phosphate medicine.disease Cross-Sectional Studies chemistry Molecular Medicine business Glomerular Filtration Rate |
| Zdroj: | Infectious disorders drug targets. 21(2) |
| ISSN: | 2212-3989 |
| Popis: | Background: Human immunodeficiency virus (HIV) infection impairs renal function, thereby affecting renal phosphate metabolism. Objectives: We prospectively estimated the prevalence of phosphate abnormalities (mild, moderate to life-threatening hypophosphataemia, and hyperphosphataemia) before initiating antiretroviral therapy (ART). Methods: A cross-sectional analysis was performed on 170 consecutive newly diagnosed ARTnaive, HIV-infected patients attending our HIV/AIDS clinics over a period of one year. Fifty (50) screened HIV-negative blood donors were used for comparison (controls). Blood and urine were collected simultaneously for phosphate and creatinine assay to estimate fractional phosphate excretion (FEPi %) and glomerular filtration rate (eGFR). Results: eGFR showed significant difference between patients’ and controls’ medians (47.89ml/ min/1.73m2 versus 60ml/min/1.73m2, p 0.05. Predictors of FEPi% were age (Odds ratio, OR 0.9, p = 0.009); weight (OR 2.0, p < 0.001); CD4+ cells count predicted urine phosphate among males (p = 0.029). Conclusion: HIV infection likely induces renal insufficiency with reduced renal phosphate clearance. Thus, hyperphosphataemia is highly prevalent, and there is mild to moderate hypophosphataemia but its life-threatening form (grade 4) is rare among ART-naive HIV patients. |
| Databáze: | OpenAIRE |
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