Induction of ornithine decarboxylase activity in epidermis by a tumor promoter: Decreased response in mice maintained on a vitamin B6-deficient diet
| Autor: | Mario Froscio, Andrew W. Murray |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
medicine.medical_specialty
Carboxy-Lyases Biophysics Biology Ornithine Decarboxylase Biochemistry Ornithine decarboxylase activity Cofactor Ornithine decarboxylase Mice chemistry.chemical_compound Internal medicine medicine Animals Trypsin Molecular Biology Pyridoxal Skin integumentary system Epidermis (botany) Pyridoxine Cell Biology Phorbols Molecular biology Kinetics Endocrinology chemistry Enzyme Induction Pyridoxal Phosphate biology.protein Tetradecanoylphorbol Acetate Female Vitamin b6 Vitamin B 6 Deficiency medicine.drug |
| Zdroj: | Biochemical and Biophysical Research Communications. 77:693-699 |
| ISSN: | 0006-291X |
| DOI: | 10.1016/s0006-291x(77)80034-x |
| Popis: | Summary Epidermal ornithine decarboxylase (EC 4.1.1.17; L-ornithine carboxy-lyase) activity was rapidly induced after the treatment of mouse skin with 12-O-tetradecanoyl phorbol-13-acetate. Induction was significantly decreased in animals maintained for 10–14 days on a vitamin B 6 -deficient diet, and could be completely restored by the injection of deficient animals with pyridoxine. As predicted, decarboxylase activity in epidermal extracts was sensitive to proteolytic attack (trypsin) in the absence of pyridoxal 5′-phosphate, and was protected from attack by the presence of the cofactor. |
| Databáze: | OpenAIRE |
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