Early renal and vascular damage within the normoalbuminuria condition
| Autor: | Jesús Vázquez, Luis M. Ruilope, Gema Ruiz-Hurtado, Maria G. Barderas, Juan Antonio López, Aranzazu Santiago-Hernandez, Marta Martin-Lorenzo, María Gómez-Serrano, Vanesa Esteban, Angeles Heredero, Gloria Alvarez-Llamas, Paula J. Martinez, Gonzalo Aldamiz-Echevarria, Julian Segura, Pablo Cannata |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Urinalysis Physiology Inflammation Kidney Renin-Angiotensin System chemistry.chemical_compound Internal medicine Internal Medicine medicine Albuminuria Humans Subclinical infection Creatinine medicine.diagnostic_test business.industry Albumin Odds ratio medicine.anatomical_structure Endocrinology chemistry Hypertension medicine.symptom Cardiology and Cardiovascular Medicine business |
| Zdroj: | Journal of hypertension. 39(11) |
| ISSN: | 1473-5598 |
| Popis: | OBJECTIVE A continuous association between albuminuria and cardiorenal risk exists further below moderately increased albuminuria ranges. If only based in albumin to creatinine ratio (ACR) higher than 30 mg/g, a significant percentage of individuals may be out of the scope for therapeutic management. Despite epidemiological outcomes, the identification of biochemical changes linked to early albuminuria is underexplored, and normoalbuminuric individuals are usually considered at no risk in clinical practice. Here, we aimed to identify early molecular alterations behind albuminuria development. METHODS Hypertensive patients under renin-angiotensin system (RAS) suppression were classified as control, (ACR |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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