Two‐drug fixed‐dose combinations of blood pressure‐lowering drugs as WHO essential medicines: An overview of efficacy, safety, and cost
| Autor: | Mark D. Huffman, Anubha Agarwal, Abhishek Sharma, Anthony Rodgers, David J. Heller, Raju Kanukula, Rajesh Vedanthan, Thomas R. Frieden, Sandeep P. Kishore, Esam Hari Prasad, Abdul Salam, Marc G. Jaffe |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Drug medicine.medical_specialty Combination therapy Endocrinology Diabetes and Metabolism media_common.quotation_subject Blood Pressure 030204 cardiovascular system & hematology World Health Organization Fixed dose Essential medicines 03 medical and health sciences 0302 clinical medicine Internal Medicine medicine Humans 030212 general & internal medicine Intensive care medicine Antihypertensive Agents Review Papers media_common Cause of death business.industry Guideline Drug Combinations Blood pressure Hypertension Blood pressure lowering Cardiology and Cardiovascular Medicine business |
| Zdroj: | J Clin Hypertens (Greenwich) |
| ISSN: | 1751-7176 1524-6175 |
| Popis: | Cardiovascular diseases (CVD) are the world's leading cause of death. High blood pressure (BP) is the leading global risk factor for all‐cause preventable morbidity and mortality. Globally, only about 14% of patients achieve BP control to systolic BP 60%) require two or more drugs to achieve BP control, yet poor adherence to therapy is a major barrier to achieving this control. Fixed‐dose combinations (FDCs) of BP‐lowering drugs are one means to improve BP control through greater adherence and efficacy, with favorable safety and cost profiles. The authors present a review of the supporting data from a successful application to the World Health Organization (WHO) for the inclusion of FDCs of two BP‐lowering drugs on the 21st WHO Essential Medicines List. The authors discuss the efficacy and safety of FDCs of two BP‐lowering drugs for the management of hypertension in adults, relevant hypertension guideline recommendations, and the estimated cost of such therapies. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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