TRP Channels in Insect Stretch Receptors as Insecticide Targets
| Autor: | Alexandre Nesterov, Marta Andrés, Dorsch John, Vincent L. Salgado, Ramani A. Kandasamy, Christian Spalthoff, Philipp Jähde, Nancy B. Rankl, Ben Warren, Lynn Stam, Franz-Josef Braun, Martin C. Göpfert, Radoslav Katana |
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| Rok vydání: | 2015 |
| Předmět: |
Arthropod Antennae
0106 biological sciences animal structures Neuroscience(all) Movement media_common.quotation_subject Action Potentials CHO Cells Insect 01 natural sciences Ion Channels Animals Genetically Modified Toxicology 03 medical and health sciences Transient receptor potential channel Cricetulus Transient Receptor Potential Channels Ion channel complex Pulmonary stretch receptors Animals Drosophila Proteins Gravity Sensing Pesticides Quinazolinones 030304 developmental biology media_common Neurons 0303 health sciences biology Triazines Chemistry General Neuroscience Chinese hamster ovary cell biology.organism_classification In vitro 3. Good health Cell biology 010602 entomology Acoustic Stimulation Larva Drosophila Mechanoreceptors Transcription Factors Stretch receptor |
| Zdroj: | Neuron. 86:665-671 |
| ISSN: | 0896-6273 |
| Popis: | SummaryDefining the molecular targets of insecticides is crucial for assessing their selectivity and potential impact on environment and health. Two commercial insecticides are now shown to target a transient receptor potential (TRP) ion channel complex that is unique to insect stretch receptor cells. Pymetrozine and pyrifluquinazon disturbed Drosophila coordination and hearing by acting on chordotonal stretch receptor neurons. This action required the two TRPs Nanchung (Nan) and Inactive (Iav), which co-occur exclusively within these cells. Nan and Iav together sufficed to confer cellular insecticide responses in vivo and in vitro, and the two insecticides were identified as specific agonists of Nan-Iav complexes that, by promoting cellular calcium influx, silence the stretch receptor cells. This establishes TRPs as insecticide targets and defines specific agonists of insect TRPs. It also shows that TRPs can render insecticides cell-type selective and puts forward TRP targets to reduce side effects on non-target species. |
| Databáze: | OpenAIRE |
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