Lower limb ischemia-reperfusion injury triggers a systemic inflammatory response and multiple organ dysfunction
| Autor: | Aires A.B. Barros D'Sa, Denis W. Harkin, Brian J. Rowlands, M. Isla Halliday, Magdi M.I. Yassin |
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| Rok vydání: | 2002 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Multiple Organ Failure Ischemia Aspartate transaminase Kidney chemistry.chemical_compound Internal medicine medicine Animals Rats Wistar Lung Creatinine biology business.industry Interleukin-6 Tumor Necrosis Factor-alpha Organ dysfunction medicine.disease Systemic Inflammatory Response Syndrome Surgery Hindlimb Rats Disease Models Animal medicine.anatomical_structure Endocrinology chemistry Alanine transaminase Liver Reperfusion Injury biology.protein medicine.symptom Complication business Reperfusion injury |
| Zdroj: | World journal of surgery. 26(1) |
| ISSN: | 0364-2313 |
| Popis: | Restoration of blood flow to an acutely ischemic lower limb may, paradoxically, result in systemic complications and unexpected mortality. We investigated the effect of acute ischemia-perfusion of the lower limb on cytokine production and end organ function. Plasma concentrations of tumor necrosis factor-alpha (TNF-a) and interleukin-6 (IL-6) were determined in five groups of male Wistar rats: control, 3 hours of bilateral hind limb ischemia alone, and 3 hours of bilateral hind limb ischemia followed by 1 hour, 2 hours, or 3 hours of reperfusion, respectively. In a second experiment, the effect of lower limb ischemia-reperfusion on remote organs (lung, liver, and kidney) was assessed biochemically and histologically. There was a significant increase in plasma concentrations of TNF-a in plasma of animals subjected to 3 hours of bilateral hind limb ischemia followed by 1 hour of reperfusion, 40.1 +/- 4.4 pg/ml, when compared with controls, 22.6 +/- 4.4 pg/ml, or animals in the ischemia-alone group, 16.3 +/- 5.2 (p |
| Databáze: | OpenAIRE |
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