Carotid- intima media thickness is independently associated with cognitive decline. The INVADE study
| Autor: | C. Briesenick, Thorleif Etgen, Holger Poppert, Hans Förstl, K. Sander, Horst Bickel, Dirk Sander |
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| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Carotid Artery Common Developmental psychology Cohort Studies Predictive Value of Tests Risk Factors Internal medicine medicine Dementia Humans Risk factor Cognitive decline Aged Aged 80 and over Psychiatric Status Rating Scales Cognitive disorder Age Factors Cognition medicine.disease Psychiatry and Mental health Intima-media thickness Multivariate Analysis cardiovascular system Geriatric Depression Scale Female Geriatrics and Gerontology Psychology Cognition Disorders Tunica Intima Tunica Media Cohort study |
| Zdroj: | International journal of geriatric psychiatry. 25(4) |
| ISSN: | 1099-1166 |
| Popis: | Objectives Increased carotid intima-media thickness (C-IMT) is a non-invasive marker of atherosclerosis and predicts vascular events. Moreover, increasing evidence suggests an association between carotid atherosclerosis and cognitive decline. The purpose of this study is to investigate the relationship between C-IMT and the development of cognitive impairment in a large population-based sample. Methods This study was based on the data of the participants of the INVADE (Intervention project on cerebrovascular diseases and dementia in the district of Ebersberg, Bavaria) project. Vascular risk factors, Geriatric depression scale (GDS) and “6 Item Cognitive Impairment Test” (6CIT) were evaluated at baseline and after 2 years. The relationship between C-IMT and cognitive impairment was analysed using multivariate logistic regression. Results Complete baseline data were available in 3386 subjects (mean age 67.7 [95% confidence interval (CI): 67.5, 68.0] years, 41% male). During follow-up, 174 subjects developed a new cognitive impairment. In the subgroup without cognitive impairment at baseline a significant association between cognitive decline after 2 years and elevated C-IMT at baseline could be detected with a significantly higher baseline C-IMT in those with cognitive decline (0.87 mm vs. 0.78 mm; p |
| Databáze: | OpenAIRE |
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