The Anti-atherosclerotic Dipeptide, Trp-His, Reduces Intestinal Inflammation through the Blockade of L-Type Ca2+ Channels
| Autor: | Jennifer Kovacs-Nolan, Yutaro Kobayashi, Toshiro Matsui, Yoshinori Mine |
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| Rok vydání: | 2015 |
| Předmět: |
Agonist
Vascular smooth muscle Calcium Channels L-Type medicine.drug_class Anti-Inflammatory Agents Pharmacology Inflammatory bowel disease Mice medicine Animals Humans Channel blocker Colitis Mice Inbred BALB C Tumor Necrosis Factor-alpha Chemistry Interleukin-8 Interleukin Dipeptides General Chemistry Inflammatory Bowel Diseases medicine.disease Intestines IκBα Immunology Female Tumor necrosis factor alpha General Agricultural and Biological Sciences |
| Zdroj: | Journal of Agricultural and Food Chemistry. 63:6041-6050 |
| ISSN: | 1520-5118 0021-8561 |
| DOI: | 10.1021/acs.jafc.5b01682 |
| Popis: | Trp-His, the anti-atherosclerotic dipeptide, exerted an antiproliferative effect on vascular smooth muscle cells by L-type Ca(2+) channel blocker-like effect. The beneficial potential by the blockade of Ca(2+) channels on chronic intestinal inflammation, including inflammatory bowel disease (IBD), is unclear. Trp-His (100 or 250 mg/kg body weight/day) was administered for 14 days to BALB/c mice, and 5% dextran sodium sulfate (DSS) was administered to induce colitis in the last 7 days. Trp-His reduced DSS-induced typical colitis symptoms and cytokine expression in the colon. Trp-His inhibited interleukin (IL)-8 secretion in tumor necrosis factor (TNF)-α-stimulated HT-29 cells. The inhibitory effect of Trp-His, as well as that of Ca(2+) channel blockers, was impaired by the presence of Ca(2+) channel agonist Bay K 8644. The TNF-α-induced activation of mitogen-activated protein kinases (MAPKs) and IκBα were decreased by Trp-His. These results indicated that the anti-inflammatory effect of Trp-His may be involved in the blockade of L-type Ca(2+) channels. |
| Databáze: | OpenAIRE |
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