Cystatin C and renal function in pediatric kidney transplant recipients
| Autor: | Maria do Carmo Franco, Samantha Santiago Nagasako, José Osmar Medina Pestana, Paula Goulart Pinheiro Machado, Ricardo Sesso, Paulo Cesar Koch Nogueira |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Urology Renal function Ocean Engineering urologic and male genital diseases Kidney transplant chemistry.chemical_compound Impaired renal function Internal medicine Medicine Humans Cystatin C Child Children lcsh:QH301-705.5 reproductive and urinary physiology Creatinine lcsh:R5-920 biology business.industry urogenital system Case-control study medicine.disease Kidney Transplantation female genital diseases and pregnancy complications Endocrinology chemistry lcsh:Biology (General) Case-Control Studies biology.protein Female Cutoff point Glomerular filtration rate business lcsh:Medicine (General) Biomarkers Kidney disease |
| Zdroj: | Brazilian Journal of Medical and Biological Research, Vol 42, Iss 12, Pp 1225-1229 (2009) Brazilian Journal of Medical and Biological Research, Volume: 42, Issue: 12, Pages: 1225-1229, Published: DEC 2009 Brazilian Journal of Medical and Biological Research v.42 n.12 2009 Brazilian Journal of Medical and Biological Research Associação Brasileira de Divulgação Científica (ABDC) instacron:ABDC |
| Popis: | In clinical practice, the glomerular filtration rate (GFR) is often determined with serum creatinine. However, studies have shown cystatin C to be a better parameter for the diagnosis of impaired renal function. We compared GFR estimated by plasma cystatin C with GFR estimated by serum creatinine in a sample of 50 pediatric renal transplant recipients and 24 healthy children. The correlation between GFR estimated by serum creatinine and by cystatin C was significant (r = 0.75; P < 0.001, Person’s correlation); however, in pediatric kidney transplant recipients, the GFR was 6.7 mL/min lower when determined using cystatin C rather than serum creatinine. Moreover, using GFR estimated by cystatin C we found that 42% of the pediatric kidney transplant recipients had an estimated GFR |
| Databáze: | OpenAIRE |
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