Monoclonal Antibodies Specific for Sendai Virus
| Autor: | M. Fenner, Hans Binz, K Siegmann |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
medicine.drug_class
Immunology Antibodies Viral Monoclonal antibody Epitope Immunoglobulin Idiotypes Viral Envelope Proteins Antigen Antibody Specificity medicine Antigens Viral Antiserum HN Protein biology Chemistry Antibodies Monoclonal Viral Vaccines General Medicine biology.organism_classification Primary and secondary antibodies Virology Molecular biology Sendai virus Antibodies Anti-Idiotypic Parainfluenza Virus 1 Human Polyclonal antibodies Immunoglobulin G Monoclonal biology.protein Viral Fusion Proteins |
| Zdroj: | Scandinavian Journal of Immunology. 24:341-349 |
| ISSN: | 0300-9475 |
| Popis: | The monoclonal antibodies A and B specific for the HN molecule of Sendai virus were used to induce polyclonal and monoclonal anti-idiotypic antibodies. No response was observed in allogeneic Lewis rats, low responses in syngeneic LOU rats, and high responses in allogeneic BN rats and xenogeneic Balb/c mice. The monoclonals A and B share a similar or identical idiotype, since polyclonal anti-idiotypic antisera to antibody A cross-reacted completely with antibody B and vice versa. The same was found with the three monoclonal anti-idiotypes 1, 2, and 3 elicited in a BN rat or in Balb/c mice. None of the polyclonal or monoclonal anti-idiotypes reacted with other monoclonal antibodies specific for Sendai virus, even when these recognized the same epitope as antibodies A and B. The monoclonal anti-idiotypic antibodies could be used to induce anti-Sendai antibodies in BN rats. |
| Databáze: | OpenAIRE |
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