Does Botulinum Toxin Therapy Improve Quality of Life in Patients with Facial Palsy?
| Autor: | Jordan Fuzi, Catherine Meller, Alon Taylor, Anders Sideris |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Population Facial Paralysis MEDLINE 030230 surgery Cochrane Library Cohort Studies 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Quality of life medicine Humans Botulinum Toxins Type A Intensive care medicine Adverse effect education education.field_of_study Palsy business.industry Evidence-based medicine Botulinum toxin Treatment Outcome Neuromuscular Agents Quality of Life Surgery business medicine.drug |
| Zdroj: | Aesthetic plastic surgery. 44(5) |
| ISSN: | 1432-5241 |
| Popis: | To review the current literature for the efficacy of botulinum toxin therapy to improve quality of life in patients with facial palsy. A comprehensive systematic literature search was performed of the Medline, EMBase, PubMed and Cochrane Library databases. The population of interest was patients with facial palsy and the intervention of interest was botulinum toxin injection. The primary outcome of this review was quality of life outcomes before and after treatment. Six studies were included for review. Outcome data were not amenable to meta-analysis due to the heterogeneity of outcome measures. There was an overall trend towards improvement in quality of life after botulinum toxin therapy with the majority of studies demonstrating a statistically significant benefit. The aspects of life in which patients saw benefit varied amongst studies. No patient factors were identified to predict which sub-cohort would likely have the greatest benefit from therapy. Two studies reported adverse effects to be common however minor in nature. This review presents contemporary evidence that botulinum toxin is of benefit to the quality of life of patients with facial palsy. Additional larger randomised control trials would aid clinicians in quantifying the benefit of such therapies for patients with facial palsy. This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 . |
| Databáze: | OpenAIRE |
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