In vitro and in vivo efficacy of a novel fluoro-ketolide HMR 3562 against enterococci
| Autor: | Alain Bonnefoy, Carole Delachaume, Pascal Le Priol, Valérie Steier, Michele Guitton |
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| Rok vydání: | 2001 |
| Předmět: |
Microbiology (medical)
Male Erythromycin Microbial Sensitivity Tests Peritonitis Microbiology Mice In vivo polycyclic compounds medicine Animals Pharmacology (medical) Ketolide Antibacterial agent Pharmacology Mice Inbred C3H biology fungi Biological activity Vancomycin Resistance biochemical phenomena metabolism and nutrition biology.organism_classification Streptococcaceae In vitro Anti-Bacterial Agents Mice Inbred C57BL Infectious Diseases Enterococcus Macrolides medicine.drug |
| Zdroj: | The Journal of antimicrobial chemotherapy. 48(1) |
| ISSN: | 0305-7453 |
| Popis: | The in vitro activity of HMR 3562, a new 2-fluoro-ketolide drug, was investigated against 95 enterococci, including 36 vancomycin-resistant strains. HMR 3562 inhibited 90% of enterococci susceptible or resistant to erythromycin A at 0.005 and 0.6 mg/L, respectively. HMR 3562 was highly active in murine peritonitis induced by five enterococci, irrespective of resistance phenotype, displaying effective doses in the range 3.4-21.8 mg/kg. The results demonstrate the potential of HMR 3562 in the treatment of infections caused by multiresistant enterococci. |
| Databáze: | OpenAIRE |
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