The effect of BCG, zymosan andCoxiella burnettiextract onEimeriainfections
| Autor: | Nicholas Smith, K.S. Ovington |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Lipopolysaccharides
0301 basic medicine animal diseases Immunology Priming (immunology) Biology Eimeria Microbiology Excretion Mice 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine In vivo parasitic diseases medicine Animals Immunology and Allergy Mice Inbred BALB C Hyperactivation Coccidiosis Tumor Necrosis Factor-alpha Zymosan food and beverages Cell Biology medicine.disease biology.organism_classification Mycobacterium bovis Rats Mice Inbred C57BL 030104 developmental biology chemistry Coxiella burnetii Female Tumor necrosis factor alpha Chickens Eimeria tenella 030215 immunology |
| Zdroj: | Immunology and Cell Biology. 74:346-348 |
| ISSN: | 0818-9641 |
| DOI: | 10.1038/icb.1996.61 |
| Popis: | Infection of animals with species of Eimeria induces a hyper-reactivity to endotoxin as manifest by a greatly increased capacity of infected animals to produce TNF in response to LPS in vivo compared with uninfected animals. This finding indicates priming for hyperactivation of macrophages by Eimeria infection and raises the possibility that non-specific triggering of macrophages by agents such as Bacille Calmette-Guerin (BCG), zymosan or Coxiella burnetti extract may be a simple means of control for coccidiosis. However, all of these agents enhanced oocyst excretion in mice, rats or chickens infected with Eimeria vermiformis, Eimeria nieschulzi or Eimeria tenella, respectively, without affecting the patent period. |
| Databáze: | OpenAIRE |
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