HemaMax™, a Recombinant Human Interleukin-12, Is a Potent Mitigator of Acute Radiation Injury in Mice and Non-Human Primates

Autor: Lena A. Basile, Dolph D. Ellefson, Sarita R. Mendonca, Jamie Tom, Zoya Gluzman-Poltorak, Joseph D. Miller, Vernon Mar, Katiana S. Junes-Gill, Alice T Trinh, Timothy K. Gallaher
Rok vydání: 2012
Předmět:
Male
Anatomy and Physiology
Myeloid
Lipopolysaccharide Receptors
lcsh:Medicine
Mice
Immune Physiology
Intestine
Small
Blood plasma
lcsh:Science
Multidisciplinary
Receptors
Interleukin-12
Total body irradiation
Interleukin-12
Recombinant Proteins
Radiation Injuries
Experimental
Dose–response relationship
Haematopoiesis
Treatment Outcome
medicine.anatomical_structure
Medicine
Female
Megakaryocytes
Research Article
Biotechnology
medicine.drug
Drugs and Devices
medicine.medical_specialty
Immunology
Biology
Interferon-gamma
Pharmacokinetics
Internal medicine
medicine
Animals
Humans
Osteoblasts
Dose-Response Relationship
Drug
lcsh:R
Radiobiology
Molecular Development
Hematopoietic Stem Cells
Macaca mulatta
Hematopoiesis
Mice
Inbred C57BL
Endocrinology
Gene Expression Regulation
Erythropoietin
Immune System
Pharmacodynamics
Leukocytes
Mononuclear
Clinical Immunology
lcsh:Q
Biomarkers
Developmental Biology
Zdroj: PLoS ONE, Vol 7, Iss 2, p e30434 (2012)
PLoS ONE
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0030434
Popis: HemaMax, a recombinant human interleukin-12 (IL-12), is under development to address an unmet medical need for effective treatments against acute radiation syndrome due to radiological terrorism or accident when administered at least 24 hours after radiation exposure. This study investigated pharmacokinetics, pharmacodynamics, and efficacy of m-HemaMax (recombinant murine IL-12), and HemaMax to increase survival after total body irradiation (TBI) in mice and rhesus monkeys, respectively, with no supportive care. In mice, m-HemaMax at an optimal 20 ng/mouse dose significantly increased percent survival and survival time when administered 24 hours after TBI between 8-9 Gy (p
Databáze: OpenAIRE
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