Forsythiaside A alleviates renal damage in adriamycin-induced nephropathy
| Autor: | She Feng Zheng, Jinnv Liu, Chan Lu |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Urinary system Chemokine CXCL2 030209 endocrinology & metabolism Kidney Nephropathy Superoxide dismutase Rats Sprague-Dawley 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Lactate dehydrogenase Malondialdehyde medicine Animals Humans Glycosides Creatinine Proteinuria biology L-Lactate Dehydrogenase business.industry Superoxide Dismutase Transcription Factor RelA medicine.disease Survival Analysis Disease Models Animal 030104 developmental biology Endocrinology chemistry Doxorubicin biology.protein Cytokines Kidney Diseases medicine.symptom business Nephrotic syndrome |
| Zdroj: | Frontiers in bioscience (Landmark edition). 25(3) |
| ISSN: | 2768-6698 |
| Popis: | Nephrotic syndrome (NS) is a common urinary system disease that carries a poor progrnosis due to nonresponsivess to current treatments. The purpose of this study was to investigate the therapeutic effects of Forsythiaside (FA) in a rat model of adriamycin-induced nephropathy (AN). Compared with control group, FA treatment significantly reduced proteinuria, serum creatinine and urea nitrogen levels and reduced the number of apoptotic cells in the kidneys. FA alleviated Adr induced renal injury, and increased the sactivity of superoxide dismutase (SOD), while decreasing malondialdehyde (MDA) and lactate dehydrogenase (LDH) in the serum. In addition, FA, in a dose-dependent manner, decreased the levels of NF-kappaBp65/MIP-2 in the kidenys, reduced the serum level of pro-inflammatory cytokines (IL-6, IL-1 β and TNF-alpha), and increased the survival rate of Adr treated rats. Taken together, the results show that FA alleviates renal dysfunction in adriamycin-induced nephropathy rats. |
| Databáze: | OpenAIRE |
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