Association of a novel single nucleotide polymorphism, G(-248)A, in the 5'-UTR of BAX gene in chronic lymphocytic leukemia with disease progression and treatment resistance

Autor:	David P. Sheridan, Oksana Moshynska, Koravangattu Sankaran, Anurag Saxena, Sathiyanarayanan Viswanathan
Rok vydání:	2002
Předmět:	Male Cancer Research Five prime untranslated region Chronic lymphocytic leukemia medicine.medical_treatment Blotting Western Molecular Sequence Data Single-nucleotide polymorphism Polymorphism Single Nucleotide hemic and lymphatic diseases Proto-Oncogene Proteins Gene expression Antineoplastic Combined Chemotherapy Protocols medicine Humans Promoter Regions Genetic Gene Cyclophosphamide Aged bcl-2-Associated X Protein Aged 80 and over Chemotherapy Base Sequence business.industry Middle Aged medicine.disease Leukemia Lymphocytic Chronic B-Cell Treatment Outcome Oncology Proto-Oncogene Proteins c-bcl-2 Cell culture Doxorubicin Drug Resistance Neoplasm Vincristine Case-Control Studies Immunology Cancer research Disease Progression Prednisone Female business 5' Untranslated Regions Pharmacogenetics
Zdroj:	Cancer letters. 187(1-2)
ISSN:	0304-3835
Popis:	In B-cell chronic lymphocytic leukemia (CLL) a high Bcl-2/Bax ratio contributes to death defiance. We sought to identify any genetic changes in the BAX as a possible mechanism for its altered expression in CLL. The BAX gene from the RL cell line and B-cells from 34 CLL patients and 25 controls were sequenced. A novel heterozygous G(−248)A polymorphism in the 5′-UTR was present in 69% of stage I–IV patients and 5.5% of stage 0 patients, and in 4.0% of controls. It was associated with reduced protein expression ( P =0.049), progression beyond Rai stage 0 ( P =0.00018) and failure to achieve complete response ( P =0.038).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cd1bb075ab7d50d40db4235c9ffd2ee https://pubmed.ncbi.nlm.nih.gov/12359369 Zobrazit plný text záznamu Full Text from ScienceDirect