Two-layer Electrospun System Enabling Wound Exudate Management and Visual Infection Response
Autor: | Giuseppe Tronci, Mohamed Basel Bazbouz |
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Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
bromothymol blue
Chronic wound Two layer Applied Physics (physics.app-ph) 02 engineering and technology lcsh:Chemical technology 01 natural sciences Biochemistry Analytical Chemistry fibres chemistry.chemical_compound Bromothymol blue lcsh:TP1-1185 Instrumentation Alanine Biological Dressings Wound.exudate Physics - Applied Physics Hydrogen-Ion Concentration 021001 nanoscience & nanotechnology Atomic and Molecular Physics and Optics Electrospinning colour change free surface electrospinning medicine.symptom Swelling 0210 nano-technology core-shell fibres Exudate FOS: Physical sciences Color 010402 general chemistry Article Polymethacrylic Acids Drug Resistance Bacterial medicine Humans Electrical and Electronic Engineering Acrylic acid Wound Healing technology industry and agriculture Water Physics - Medical Physics infection 0104 chemical sciences chemistry Bromthymol Blue Wound Infection Nanoparticles Wounds and Injuries Medical Physics (physics.med-ph) Biomedical engineering |
Zdroj: | Sensors (Basel, Switzerland) Sensors Volume 19 Issue 5 Sensors, Vol 19, Iss 5, p 991 (2019) |
ISSN: | 1424-8220 |
Popis: | The spread of antimicrobial resistance calls for chronic wound management devices that can engage with the wound exudate and signal infection by prompt visual effects. Here, the manufacture of a two-layer fibrous device with independently-controlled exudate management capability and visual infection responsivity was investigated by sequential free surface electrospinning of poly(methyl methacrylate-co-methacrylic acid) (PMMA-co-MAA) and poly(acrylic acid) (PAA). By selecting wound pH as infection indicator, PMMA-co-MAA fibres were encapsulated with halochromic bromothymol blue (BTB) to trigger colour changes at infection-induced alkaline pH. Likewise, the exudate management capability was integrated via the synthesis of a thermally-crosslinked network in electrospun PAA layer. PMMA-co-MAA fibres revealed high BTB loading efficiency (> 80 wt.%) and demonstrated prompt colour change and selective dye release at infected-like media (pH > 7). The synthesis of the thermally-crosslinked PAA network successfully enabled high water uptake (WU = 1291 ± 48 &minus 2369 ± 34 wt.%) and swelling index (SI = 272 ± 4 &minus 285 ± 3 a.%), in contrast to electrospun PAA controls. This dual device functionality was lost when the same building blocks were configured in a single-layer mesh of core-shell fibres, whereby significant BTB release (~70 wt.%) was measured even at acidic pH. This study therefore demonstrates how the fibrous configuration can be conveniently manipulated to trigger structure-induced functionalities critical to chronic wound management and monitoring. |
Databáze: | OpenAIRE |
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