Characterization of rat encephalitogenic T cells bearing non-V beta 8 T cell receptors
| Autor: | Deming Sun, Daniel P. Gold, Lawrence R. Smith, Steven Brostoff, Christopher Coleclough |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Encephalomyelitis
Autoimmune Experimental T cell Receptors Antigen T-Cell alpha-beta Immunology Molecular Sequence Data Biology Polymerase Chain Reaction Epitope Epitopes T-Lymphocyte Subsets medicine Immunology and Allergy Cytotoxic T cell Animals IL-2 receptor Amino Acid Sequence Gene Rearrangement beta-Chain T-Cell Antigen Receptor Antigen-presenting cell Hybridomas Base Sequence Myelin Basic Protein T lymphocyte Natural killer T cell Molecular biology Myelin basic protein Rats medicine.anatomical_structure Biochemistry Oligodeoxyribonucleotides Rats Inbred Lew biology.protein |
| Zdroj: | European journal of immunology. 22(2) |
| ISSN: | 0014-2980 |
| Popis: | In this study, we demonstrate that T cell lines specific for a synthetic peptide representing sequence 87 to 99 of myelin basic protein (MBP) are encephalitogenic in Lewis rats. However, unlike syngeneic T cells specific for MBP residues 68 to 88 which exclusively use V beta 8 in their antigen receptors, these cells do not. None of the 10 T cell lines and T hybridomas specific for MBP (87-99) used V beta 8 in their T cell receptors. Our results document for the first time that rat encephalitogenic T cells do not exclusively use V beta 8 in T cell receptors that rat encephalitogenic T cells specific for MBP (87-99) are heterogeneous and that MBP (87-99) contains at least two epitopes for rat T cells. |
| Databáze: | OpenAIRE |
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