Skewed Expression of Activation, Differentiation and Homing-Related Antigens in Circulating Cells from Patients with Cutaneous T Cell Lymphoma Associated with CD7– T Helper Lymphocytes Expansion
| Autor: | Enrico Scala, Pietro Puddu, Ornella De Pità, Carlo Renè Girardelli, S. Cadoni, Giandomenico Russo, Maria Grazia Narducci |
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| Rok vydání: | 1999 |
| Předmět: |
Male
Skin Neoplasms Dipeptidyl Peptidase 4 Lymphoproliferative disorders Antigens CD7 Dermatology CD45R0 Biology CD49d Lymphocyte Activation Biochemistry Antigen Antigens CD T-Lymphocyte Subsets CD60 hemic and lymphatic diseases medicine CD15s Humans Sezary Syndrome Molecular Biology CD26 Aged Mycosis fungoides Cutaneous T-cell lymphoma VLA4 T lymphocyte T-Lymphocytes Helper-Inducer Cell Biology Middle Aged medicine.disease Lymphoma Lymphoma T-Cell Cutaneous Immunology Female CD8 |
| Zdroj: | Journal of Investigative Dermatology. 113(4):622-627 |
| ISSN: | 0022-202X |
| DOI: | 10.1046/j.1523-1747.1999.00718.x |
| Popis: | Mycosis fungoides and Sézary syndrome represent the most frequent forms of cutaneous T cell lymphoma. Both are characterized by skin infiltrating and/or circulating malignant cells displaying a CD4+CD7– phenotype in the majority of cases. Because an expansion of CD4+CD7– cells may also be found in inflammatory dermatoses or in the aging process, we evaluated, by flow cytometry, the relationship between CD7 expression and the distribution of differentiation/activation or homing antigens on peripheral blood lymphocytes from 36 cutaneous T cell lymphoma patients and from healthy donors. CD4+CD7– cells were increased in all patients with cutaneous T cell lymphoma. As a consequence, the CD7+/– ratio was reduced in stage I–II mycosis fungoides (3.96 vs 6.55 in healthy donors), and inverted in stage III–IV MF and Sézary syndrome (0.28 and 0.12 respectively). In the late stage of disease, the CD7+/– inverted ratio was strictly related to the expression of CD15s, CD60, and CD45R0, and the lack of expression of CD26 and CD49d. Interestingly, in leukemic patients, this phenotype was also associated with peculiar morphologic (large size) or phenotypical (CD3dim expression) characteristics. Furthermore, a progressive reduction of circulating CD8+ cells was also seen throughout all stages of disease. The presence of these populations in cutaneous T cell lymphoma at late phases of disease and Sézary syndrome suggests that all of these molecules may play an important part in the activation pathway and skin homing of circulating T cells in lymphoproliferative disorders. Therefore, this may constitute a distinctive feature in cutaneous T cell lymphoma patients with more aggressive characteristics. |
| Databáze: | OpenAIRE |
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