Platelet indices in stable chronic obstructive pulmonary disease – association with inflammatory markers, comorbidities and therapy
| Autor: | Andrea Vukić Dugac, Dunja Rogić, Lada Rumora, Tihana Žanić Grubišić, Sanja Popović-Grle, Iva Hlapčić, Anita Somborac-Bačura, Ivana Rako |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
Lymphocyte blood platelets Clinical Biochemistry 030204 cardiovascular system & hematology Fibrinogen Gastroenterology BIOMEDICINE AND HEALTHCARE. Pharmacy. Medical Biochemistry Pulmonary Disease Chronic Obstructive 0302 clinical medicine Adrenal Cortex Hormones Forced Expiratory Volume Leukocytes Platelet BIOMEDICINA I ZDRAVSTVO. Farmacija. Medicinska biokemija Lymphocytes Aged 80 and over COPD medicine.diagnostic_test Platelet Distribution Width Complete blood count Middle Aged medicine.anatomical_structure Cardiovascular Diseases Female medicine.drug Blood Platelets medicine.medical_specialty chronic obstructive pulmonary disease 03 medical and health sciences inflammation therapy Metabolic Diseases Internal medicine medicine Humans Mean platelet volume Adrenergic beta-2 Receptor Agonists Aged Lung business.industry Biochemistry (medical) Original Articles medicine.disease Logistic Models 030228 respiratory system Case-Control Studies business Biomarkers |
| Zdroj: | Biochemia Medica Volume 30 Issue 1 |
| ISSN: | 1330-0962 1846-7482 |
| Popis: | Chronic obstructive pulmonary disease (COPD) is a complex inflammatory condition that can affect haemostasis. This study aimed to determine differences in platelet-related parameters between controls and COPD subjects. The hypothesis was that platelet indices are disturbed in COPD patients, and this would be accompanied by increased C-reactive protein (CRP), fibrinogen (Fbg) and white blood cells (WBC). Therefore, platelet count (Plt), platelet-related parameters – mean platelet volume (MPV), platelet distribution width (PDW), plateletcrit (Pct), their ratios (MPV/Plt, MPV/Pct, PDW/Plt, PDW/Pct), platelet to lymphocyte ratio (PLR), Plt index as well as CRP, Fbg and WBC were assessed. Materials and methods: Study included 109 patients with stable COPD and 95 control subjects, recruited at Clinical Department for Lung Diseases Jordanovac, University Hospital Centre Zagreb (Zagreb, Croatia). Complete blood count was performed on Sysmex XN-1000, CRP on Cobas c501, and Fbg on BCS XP analyser. Data were analysed with MedCalc statistical software. Results: Platelet (P = 0.007) and PLR (P = 0.006) were increased, while other platelet indices were decreased in COPD patients compared to controls. Combined model that included PLR, PDW and WBC showed great diagnostic performances, and correctly classified 75% of cases with an AUC of 0.845 (0.788 – 0.892), P < 0.001. Comorbidities (cardiovascular or metabolic diseases) had no effect on investigated parameters, while inhaled corticosteroids/long-acting β2-agonists (ICS/LABA) therapy increased MPV and PDW values in COPD patients. Conclusion: Platelet indices were altered in COPD patients and they could be valuable as diagnostic markers of COPD development, especially if combined with already known inflammatory markers. |
| Databáze: | OpenAIRE |
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