Vitamin D Status in Women with Gestational Diabetes Mellitus during Pregnancy and Postpartum
| Autor: | Lukáš Pácal, Josef Tomandl, Vendula Bartáková, Anna Pleskačová, Jana Bělobrádková, Kateřina Kaňková, Katarína Kuricová |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Adult
medicine.medical_specialty endocrine system diseases Article Subject Blood sugar lcsh:Medicine 030209 endocrinology & metabolism General Biochemistry Genetics and Molecular Biology vitamin D deficiency 03 medical and health sciences 0302 clinical medicine Insulin resistance Pregnancy Diabetes mellitus Internal medicine medicine Vitamin D and neurology Humans 030212 general & internal medicine Vitamin D reproductive and urinary physiology General Immunology and Microbiology Anthropometry Obstetrics business.industry Postpartum Period lcsh:R nutritional and metabolic diseases General Medicine medicine.disease female genital diseases and pregnancy complications Gestational diabetes Diabetes Gestational Endocrinology Female business Postpartum period Research Article |
| Zdroj: | BioMed Research International, Vol 2015 (2015) BioMed Research International |
| ISSN: | 2314-6133 |
| DOI: | 10.1155/2015/260624 |
| Popis: | Of many vitamin D extraskeletal functions, its modulatory role in insulin secretion and action is especially relevant for gestational diabetes mellitus (GDM). The aims of the present study were to determine midgestational and early postpartum vitamin D status in pregnant women with and without GDM and to describe the relationship between midgestational and postpartum vitamin D status and parallel changes of glucose tolerance. A total of 76 pregnant women (47 GDM and 29 healthy controls) were included in the study. Plasma levels of 25(OH)D were measured using an enzyme immunoassay. Vitamin D was not significantly decreased in GDM compared to controls during pregnancy; however, both groups of pregnant women exhibited high prevalence of vitamin D deficiency. Prevalence of postpartum 25(OH)D deficiency in post-GDM women remained significantly higher and their postpartum 25(OH)D levels were significantly lower compared to non-GDM counterparts. Finally, based on the oGTT repeated early postpartum persistent glucose abnormality was ascertained in 15% of post-GDM women; however, neither midgestational nor postpartum 25(OH)D levels significantly differed between subjects with GDM history and persistent postpartum glucose intolerance and those with normal glucose tolerance after delivery. |
| Databáze: | OpenAIRE |
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