The iron link between malaria and invasive non-typhoid Salmonella infections
| Autor: | Dorine W. Swinkels, Susanne van Santen, André J. A. M. van der Ven, Quirijn de Mast |
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| Rok vydání: | 2013 |
| Předmět: |
Salmonella
Erythrocytes Iron Plasmodium falciparum Iron metabolism Pathogenesis and modulation of inflammation [IGMD 7] Disease Biology medicine.disease_cause Article Microbiology Immunity medicine Global health Animals Homeostasis Humans Malaria Falciparum Child Coinfection Macrophages Iron metabolism Poverty-related infectious diseases [IGMD 7] medicine.disease biology.organism_classification Erythrophagocytosis Infectious Diseases Immunology Salmonella Infections Parasitology Poverty-related infectious diseases Infectious diseases and international health [N4i 3] Malaria |
| Zdroj: | Trends in Parasitology, 29, 5, pp. 220-7 Trends in Parasitology, 29, 220-7 |
| ISSN: | 1471-4922 |
| Popis: | Item does not contain fulltext Epidemiological studies have demonstrated an association between malaria and invasive non-typhoid Salmonella (NTS) infections, especially in children. We explore the role of iron as a possible cofactor in this association. Malarial disease, among others, is associated with enhanced erythrophagocytosis and inflammation, which increases the iron content of macrophages and thereby also the survival of Salmonella spp. within macrophages. Whether iron supplementation programs augment the risk of invasive NTS infections in malaria-endemic regions is an important global health issue that still needs to be determined. |
| Databáze: | OpenAIRE |
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