The CD70-CD27 axis in oncology: the new kids on the block
| Autor: | Flieswasser, Tal, Van den Eynde, Astrid, Van Audenaerde, Jonas, De Waele, Jorrit, Lardon, Filip, Riether, Carsten, de Haard, Hans, Smits, Evelien, Pauwels, Patrick, Jacobs, Julie |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Cancer Research
Neoplasms. Tumors. Oncology. Including cancer and carcinogens virus diseases hemic and immune systems chemical and pharmacologic phenomena 610 Medicine & health Review Medical Oncology Hematopoiesis Hematological malignancies CD70 Oncology immune system diseases Hematologic Neoplasms Solid tumors Humans Combination therapies Human medicine CD27 RC254-282 CD27 Ligand |
| Zdroj: | Flieswasser, Tal; Van den Eynde, Astrid; Van Audenaerde, Jonas; De Waele, Jorrit; Lardon, Filip; Riether, Carsten; de Haard, Hans; Smits, Evelien; Pauwels, Patrick; Jacobs, Julie (2022). The CD70-CD27 axis in oncology: the new kids on the block. Journal of experimental & clinical cancer research, 41(1), p. 12. BioMed Central 10.1186/s13046-021-02215-y Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-15 (2022) Journal of Experimental and Clinical Cancer Research Journal of Experimental & Clinical Cancer Research : CR |
| ISSN: | 1756-9966 |
| DOI: | 10.1186/s13046-021-02215-y |
| Popis: | The immune checkpoint molecule CD70 and its receptor CD27 are aberrantly expressed in many hematological and solid malignancies. Dysregulation of the CD70-CD27 axis within the tumor and its microenvironment is associated with tumor progression and immunosuppression. This is in contrast to physiological conditions, where tightly controlled expression of CD70 and CD27 plays a role in co-stimulation in immune responses. In hematological malignancies, cancer cells co-express CD70 and CD27 promoting stemness, proliferation and survival of malignancy. In solid tumors, only expression of CD70 is present on the tumor cells which can facilitate immune evasion through CD27 expression in the tumor microenvironment. The discovery of these tumor promoting and immunosuppressive effects of the CD70-CD27 axis has unfolded a novel target in the field of oncology, CD70.In this review, we thoroughly discuss current insights into expression patterns and the role of the CD70-CD27 axis in hematological and solid malignancies, its effect on the tumor microenvironment and (pre)clinical therapeutic strategies. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink