Co-inheritance of alpha globin gene deletion lowering serum iron level in female beta thalassemia patients
| Autor: | Sana Al-Jarrash, J. Francis Borgio, Zaki A. Naserullah, Sayed AbdulAzeez, Ahmed M. Al-Suliman, Huda I. ElFakharay, Noor B. Almandil |
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| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Iron Thalassemia Saudi Arabia Biology 03 medical and health sciences symbols.namesake 0302 clinical medicine alpha-Globins hemic and lymphatic diseases Genotype Multiplex polymerase chain reaction Genetics medicine Humans Child Alpha globulin Molecular Biology Gene Sanger sequencing medicine.diagnostic_test beta-Thalassemia Beta thalassemia General Medicine medicine.disease Molecular biology 030104 developmental biology Child Preschool 030220 oncology & carcinogenesis Serum iron symbols Female Gene Deletion |
| Zdroj: | Molecular Biology Reports. 47:603-606 |
| ISSN: | 1573-4978 0301-4851 |
| Popis: | In the Eastern province of Saudi Arabia, thalassemia is highly common. Data on the effect of alpha globin gene variation on the concentration of iron on transfusion dependent Saudis are scanty. A total of 166 transfusions dependent β-thalassemia were included in this study to understand association between the alpha globin gene variation and concentration of iron. Using multiplex PCR, the alpha globin gene deletions were identified. Also, HBA1 and HBA2 genes were sequenced by Sanger sequencing. Saudi transfusion dependent female β-thalassemia patients with wild alpha globin genotype (αα/αα) were observed with iron level beyond the normal range. However, normal range of iron was observed in transfusion dependent Saudi female beta thalassemia patients co-inherited with double (-α3.7/-α3.7, or --Fil/αα or --MED/αα or - (α) 20.5/αα) or double heterozygosity (- -/-α3.7) alpha globin gene deletions, which is significantly (p |
| Databáze: | OpenAIRE |
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