Airway inflammation and eotaxin in exhaled breath condensate of patients with severe persistent allergic asthma during omalizumab therapy
| Autor: | Roman Skiepko, M. M. Tomasiak-Lozowska, Ziemowit Zietkowski, Anna Bodzenta-Lukaszyk |
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| Rok vydání: | 2011 |
| Předmět: |
Eotaxin
Adult Chemokine CCL11 Male Time Factors Omalizumab Immunoglobulin E Antibodies Monoclonal Humanized Nitric Oxide Allergic inflammation Anti-Allergic Agents medicine Hypersensitivity Humans Exhaled breath condensate Asthma Inflammation biology business.industry Exhalation Antibodies Monoclonal General Medicine respiratory system Middle Aged medicine.disease respiratory tract diseases Antibodies Anti-Idiotypic Eosinophils Immunology Exhaled nitric oxide biology.protein Female business medicine.drug |
| Zdroj: | Advances in medical sciences. 56(2) |
| ISSN: | 1898-4002 |
| Popis: | Purpose The central role of IgE in allergic inflammation in asthma has provided a rationale for the development of omalizumab, the humanized monoclonal anti-IgE antibody. The aim of the study was to determine the effect of omalizumab treatment on changes in airway inflammatory process and eotaxin in exhaled breath condensate in patients with persistent severe allergic asthma. Material and Methods The study was performed on a group of 19 patients with severe persistent allergic asthma treated with conventional therapy (according to GINA 2006) and with or without omalizumab (9 vs 10 patients). Eotaxin in exhaled breath condensate, exhaled nitric oxide, blood eosinophil count and serum ECP were measured before and after 16 weeks of therapy. Results In the group treated with omalizumab, a statistically significant decrease in the concentrations of eotaxin in EBC, FENO, serum ECP, and blood eosinophil count after 16 weeks of treatment was observed. Statistically significant correlations were revealed between the decrease in eotaxin and the decrease in FENO, serum ECP and blood eosinophil count after omalizumab therapy. Conclusions Downregulation of eotaxin expression in the airways through limitation of eosinophilic inflammation could be essential in the beneficial effect of anti-IgE therapy with omalizumab in asthma patients. |
| Databáze: | OpenAIRE |
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