Sublingual administration of detomidine to calves prior to disbudding: a comparison with the intravenous route
| Autor: | Marianna Norring, Elina Viitasaari, Mika Scheinin, Laura Hänninen, Satu Raussi, Marja Raekallio, Kati Salla, Valtteri Rinne, Ann-Helena Hokkanen, Outi Vainio |
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| Přispěvatelé: | Departments of Faculty of Veterinary Medicine, Production Animal Medicine, Equine and Small Animal Medicine, Research Centre for Animal Welfare, DAPHNE - Developing Assessment Practices in Higher Education, Teachers' Academy |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty 040301 veterinary sciences Administration Sublingual Conscious Sedation Cattle Diseases ta3111 413 Veterinary science Sublingual administration Body Temperature calves 0403 veterinary science Anaesthesia Heart Rate Heart rate Medicine Animals Hypnotics and Sedatives ta413 ta317 Horns Detomidine Pain Postoperative oromucosal General Veterinary detomidine business.industry sedatives 0402 animal and dairy science Imidazoles 04 agricultural and veterinary sciences veterinary(all) 040201 dairy & animal science 3. Good health Surgery welfare disbudding Anesthesia Injections Intravenous Cattle Female business Gels Intravenous route medicine.drug |
| Zdroj: | Veterinary Anaesthesia and Analgesia |
| Popis: | Objective To study the effects of oromucosal detomidine gel administered sublingually to calves prior to disbudding, and to compare its efficacy with intravenously (IV) administered detomidine. Study design Randomised, prospective clinical study. Animals Twenty dairy calves aged 12.4 ± 4.4days (mean ± SD), weight 50.5 ± 9.0 kg. Methods Detomidine at 80 μg kg−1 was administered to ten calves sublingually (GEL) and at 30 μg kg−1 to ten control calves IV (V. jugularis). Meloxicam (0.5 mg kg−1) and local anaesthetic (lidocaine 3 mg kg−1) were administered before heat cauterization of horn buds. Heart rate (HR), body temperature and clinical sedation were monitored over 240 minutes. Blood was collected from the V. cephalica during the same period for drug concentration analysis. Pharmacokinetic variables were calculated from the plasma detomidine concentration-time data using non-compartmental methods. Statistical analyses compared routes of administration by Student's t-test and linear mixed models as relevant. Results The maximum plasma detomidine concentration after GEL was 2.1 ± 1.2 ng mL−1 (mean ±SD) and the time of maximum concentration was 66.0 ± 36.9 minutes. The bioavailability of detomidine was approximately 34% with GEL. Similar sedation scores were reached in both groups after administration of detomidine, but maximal sedation was reached earlier in the IV group (10 minutes) than in the GEL group (40 minutes). HR was lower after IV than GEL from 5 to 10 minutes after administration. All animals were adequately sedated, and we were able to administer local anaesthetic without resistance to all of the calves before disbudding. Conclusions and clinical relevance Oromucosally administered detomidine is an effective sedative agent for calves prior to disbudding. |
| Databáze: | OpenAIRE |
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