Nitric oxide synthase in developing retinas and after optic tract section
| Autor: | L.S Jen, J.I Patel, S.M Gentleman, L.J Garey |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Retinal Ganglion Cells
Programmed cell death Pathology medicine.medical_specialty genetic structures Optic tract Giant retinal ganglion cells Cell Count Retina Lesion Rats Sprague-Dawley Antibody Specificity medicine Animals Molecular Biology biology Cell Death General Neuroscience Optic Nerve Anatomy Denervation eye diseases Ganglion Rats Nitric oxide synthase medicine.anatomical_structure Retinal ganglion cell biology.protein sense organs Neurology (clinical) medicine.symptom Nitric Oxide Synthase Developmental Biology |
| Zdroj: | Brain research. 761(1) |
| ISSN: | 0006-8993 |
| Popis: | We compared the pattern of nitric oxide synthase (NOS) immunoreactivity in retinas of rats during normal development and after unilateral transection of the optic tract at postnatal day 7. NOS was first detected in the second postnatal week in the inner nuclear and inner plexiform layers. There was no detectable difference in the overall pattern of immunoreactivity between normal retinas and retinas with severe loss of ganglion cells due to the lesion. We suggest that NOS may have a role in synaptic and vascular development in the inner retina, but is unlikely to play a major role in normal physiological retinal ganglion cell death or axotomy-induced cell death. |
| Databáze: | OpenAIRE |
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