Withdrawing PPI Therapy After Healing Esophagitis Does Not Worsen Symptoms or Cause Persistent Hypergastrinemia: Analysis of Dexlansoprazole MR Clinical Trial Data
| Autor: | Cong Han, Betsy L. Pilmer, David C. Metz, M. Claudia Perez |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty Lansoprazole Severity of Illness Index Gastroenterology 2-Pyridinylmethylsulfinylbenzimidazoles Gastric Acid Esophagus Heartburn Internal medicine Gastrins Severity of illness medicine Esophagitis Humans Dexlansoprazole Aged Randomized Controlled Trials as Topic Retrospective Studies Withholding Treatment Hepatology business.industry Proton Pump Inhibitors Retrospective cohort study Middle Aged medicine.disease Clinical trial Female medicine.symptom business medicine.drug |
| Zdroj: | The American Journal of Gastroenterology |
| ISSN: | 0002-9270 |
| DOI: | 10.1038/ajg.2011.220 |
| Popis: | OBJECTIVES: Withdrawal of proton pump inhibitors (PPIs) may induce symptoms in healthy volunteers, suggesting that discontinuing PPI therapy induces acid-peptic disease. Similar assessments in patients with documented acid-related disorders are lacking. METHODS: We performed a retrospective analysis of data from 287 Helicobacter pylori-negative erosive esophagitis (EE) patients healed after 4 or 8 weeks of therapy with dexlansoprazole modified release (MR) or lansoprazole, and then randomized to placebo in 6-month maintenance trials. We compared serum gastrin levels and 24-h heartburn severity before enrollment in the healing trials (baseline) and after receiving placebo in the 6-month maintenance trials. RESULTS: Mean gastrin values at maintenance months 1 and 3 were essentially unchanged (median changes, 1.0 and −1.0 pg/ml), showing that gastrin normalized within 1 month of discontinuing PPIs and remained flat. Mean heartburn severity at maintenance month 1 was |
| Databáze: | OpenAIRE |
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