Effects of Cimetidine and Poldine on Nocturnal Gastric Secretion in Duodenal Ulcer
| Autor: | J.M. Cargill, J.H.B. Saunders, K.G. Wormsley |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Drug
medicine.medical_specialty medicine.drug_class media_common.quotation_subject Benzilates Guanidines chemistry.chemical_compound Pepsin Internal medicine medicine Anticholinergic Humans Secretion Circadian rhythm Cimetidine media_common Gastric Acidity Determination Gastric Juice biology business.industry Gastroenterology Pepsin A Circadian Rhythm Endocrinology chemistry Duodenal Ulcer biology.protein business Histamine medicine.drug |
| Zdroj: | Digestion. 15:452-456 |
| ISSN: | 1421-9867 0012-2823 |
| DOI: | 10.1159/000198033 |
| Popis: | Cimetidine inhibited nocturnal secretion of acid but only slightly inhibited the nocturnal secretion of pepsin in patients with duodenal ulcer. Administration of cimetidine (200 or 400 mg), together with an anticholinergic drug (poldine), augmented the inhibition of the nocturnal secretion of acid and of pepsin. The combination of an H2-receptor-blocking drug with an anticholinergic drug will have therapeutic application in the management of duodenal ulceration. |
| Databáze: | OpenAIRE |
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