Consensus Parameter: Research Methodologies to Evaluate Neurodevelopmental Effects of Pubertal Suppression in Transgender Youth

Autor: Paul E. Micevych, Tomáš Paus, Lauren Kenworthy, Agneta Herlitz, Ira Haraldsen, Gordon J. Chelune, John F. Strang, Ronald E. Dahl, Adriene M. Beltz, Eric E. Nelson, Sarah M. Burke, Megan M. Herting, Victoria D. Kolbuck, Judith L. Ross, Sheri A. Berenbaum, Julie Bakker, Sven C. Mueller, Robert Garofalo, Eveline A. Crone, Lise Eliot, Diane Chen, Gregory L. Wallace, Baudewijntje P.C. Kreukels, Cheryl L. Sisk, Kim Wallen, Eric Vilain, Laurence Steinberg, Stephen M. Rosenthal, Margaret M. McCarthy, Deborah P. Waber, Carol Lynn Martin
Přispěvatelé: Medical psychology, APH - Aging & Later Life, APH - Mental Health, Amsterdam Reproduction & Development (AR&D), APH - Personalized Medicine
Rok vydání: 2020
Předmět:
Zdroj: Transgender health, vol 5, iss 4
Transgender health
Transgender health, 5(4), 246-257. Mary Ann Liebert Inc.
Transgender Health
Transgender health, 5(4), 246-257
Chen, D, Strang, J F, Kolbuck, V D, Rosenthal, S M, Wallen, K, Waber, D P, Steinberg, L, Sisk, C L, Ross, J, Paus, T, Mueller, S C, Mccarthy, M M, Micevych, P E, Martin, C L, Kreukels, B P C, Kenworthy, L, Herting, M M, Herlitz, A, Haraldsen, I R J H, Dahl, R, Crone, E A, Chelune, G J, Burke, S M, Berenbaum, S A, Beltz, A M, Bakker, J, Eliot, L, Vilain, E, Wallace, G L, Nelson, E E & Garofalo, R 2020, ' Consensus Parameter : Research Methodologies to Evaluate Neurodevelopmental Effects of Pubertal Suppression in Transgender Youth ', Transgender health, vol. 5, no. 4, pp. 246-257 . https://doi.org/10.1089/trgh.2020.0006
TRANSGENDER HEALTH
ISSN: 2380-193X
2688-4887
DOI: 10.1089/trgh.2020.0006
Popis: Purpose: Pubertal suppression is standard of care for early pubertal transgender youth to prevent the development of undesired and distressing secondary sex characteristics incongruent with gender identity. Preliminary evidence suggests pubertal suppression improves mental health functioning. Given the widespread changes in brain and cognition that occur during puberty, a critical question is whether this treatment impacts neurodevelopment. Methods: A Delphi consensus procedure engaged 24 international experts in neurodevelopment, gender development, puberty/adolescence, neuroendocrinology, and statistics/psychometrics to identify priority research methodologies to address the empirical question: is pubertal suppression treatment associated with real-world neurocognitive sequelae? Recommended study approaches reaching 80% consensus were included in the consensus parameter. Results: The Delphi procedure identified 160 initial expert recommendations, 44 of which ultimately achieved consensus. Consensus study design elements include the following: a minimum of three measurement time points, pubertal staging at baseline, statistical modeling of sex in analyses, use of analytic approaches that account for heterogeneity, and use of multiple comparison groups to minimize the limitations of any one group. Consensus study comparison groups include untreated transgender youth matched on pubertal stage, cisgender (i.e., gender congruent) youth matched on pubertal stage, and an independent sample from a large-scale youth development database. The consensus domains for assessment includes: mental health, executive function/cognitive control, and social awareness/functioning. Conclusion: An international interdisciplinary team of experts achieved consensus around primary methods and domains for assessing neurodevelopmental effects (i.e., benefits and/or difficulties) of pubertal suppression treatment in transgender youth.
Databáze: OpenAIRE
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