Fosfomycin nebulizer therapy to chronic sinusitis
| Autor: | Zensei Matsuzaki, Jun Ogino, Yoshitaka Okamoto, Izuru Nozawa, Kazuhito Kikushima, Tomokazu Matsuoka, Shuichiro Endo, Atsushi Kamijyo |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Male Haemophilus Infections Adolescent Fosfomycin Nebulizer therapy Drug Administration Schedule Streptococcal Infections Medicine Humans In patient Sinusitis Child Aged business.industry Tumor Necrosis Factor-alpha Interleukins Nebulizers and Vaporizers Chronic sinusitis General Medicine Exudates and Transudates Middle Aged Bactericidal effect Clinical trial Nebulizer Treatment Outcome Otorhinolaryngology Anesthesia Chronic Disease Nasal Lavage Surgery Female business medicine.drug |
| Zdroj: | Auris, nasus, larynx. 28(3) |
| ISSN: | 0385-8146 |
| Popis: | Objective: effects of Fosfomycin (FOM) nebulizer therapy were studied in patients with chronic sinusitis. Methods: about 28 patients with chronic sinusitis were administered 2 ml of FOM sodium (3% w/v) by nebulizer three times per week for 4 weeks. Levels of IL-1β, IL-6, IL-8, and TNF-α in nasal lavage were also measured before and at the end of treatment. Results: the overall efficacy of this treatment on the basis of both subjective and objective symptoms, was ‘excellent’ for 28.6%, ‘good’ for 10.7%, ‘fair’ for 39.4%, and yield ‘no change’ for 21.4% of the patients. Both IL-1β and IL-6 concentrations were significantly decreased after treatment. Although the IL-8 level did not significantly decrease, it seems to be related to the overall efficacy. TNF-α was not detected in all of the samples. Conclusion: FOM nebulization therapy is highly effective in treatment for chronic sinusitis, and efficacy may be due to an immunomodulatory mechanism, as well as its bactericidal effect. |
| Databáze: | OpenAIRE |
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