Maternal air pollution exposure during the first trimester of pregnancy and markers of inflammation and endothelial dysfunction
| Autor: | Paola Mozzoni, Simona Iodice, Nicola Persico, Luca Ferrari, Silvana Pinelli, Massimo Corradi, Stefano Rossi, Michele Miragoli, Enrico Bergamaschi, Valentina Bollati, Rossella Alinovi, Annibale Biggeri, Francesca Borghi, Laura Cantone, Dolores Catelan, Andrea Cattaneo, Domenico Cavallo, Laura Dioni, Vincenza Dolo, Ilaria Giusti, Laura Grisotto, Mirjam Hoxha, Benedetta Ischia, Jacopo Mariani, Damiano Monticelli, Federica Rota, Irene Rota, Sabrina Rovelli, Andrea Spinazzè, Giorgia Stoppa, Marco Vicenzi |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Inflammation
Biomarkers Coagulation Environmental Pre-eclampsia Pregnancy Interleukin-6 Pregnancy Pre-eclampsia Biomarkers Inflammation Coagulation Environmental Fibrinogen Environmental Exposure Biochemistry Pregnancy Complications Pregnancy Trimester First Maternal Exposure Air Pollution Plasminogen Activator Inhibitor 1 Humans Female Particulate Matter General Environmental Science |
| Popis: | Maternal exposure to air pollutants has been associated with pregnancy complications and adverse birth outcomes. Endothelial dysfunction, an imbalance in vascular function, during pregnancy is considered a key element in the development of pre-eclampsia. Environmental exposure to particulate matter (PM) during the first trimester of pregnancy might increase maternal inflammatory status thus affecting fetal growth, possibly leading to preterm delivery.The purpose of the study was to evaluate possible effects of PM295 pregnant women were recruited. Individual PM exposure was assigned to each subject by calculating the mean of PMFor long-term exposure, we observed an increase in sVCAM-1 and a decrease of PAI-1 levels for each 10 μg/mThe present study showed that both long- and short-term exposures to PM are associated with changes in circulating levels of biomarkers in pregnant women reflecting systemic inflammation and endothelial dysfunction/activation. Our findings support the hypothesis that inflammation and endothelial dysfunction might have a central role in modulating the detrimental effects of air pollution exposure during pregnancy. |
| Databáze: | OpenAIRE |
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