Coronary vasa vasorum neovascularization precedes epicardial endothelial dysfunction in experimental hypercholesterolemia
| Autor: | David R. Holmes, Erik L. Ritman, Darcy M. Richardson, Joerg Herrmann, Amir Lerman, Martin Rodriguez-Porcel, Lilach O. Lerman |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
medicine.medical_specialty
Time Factors Endothelium Normal diet Swine Physiology Vasodilator Agents Hypercholesterolemia Bradykinin Neovascularization Physiology (medical) Internal medicine medicine Animals Endothelial dysfunction Analysis of Variance Neovascularization Pathologic Vascular disease business.industry Vasa Vasorum Anatomy medicine.disease Coronary Vessels Coronary arteries Disease Models Animal medicine.anatomical_structure Vasa vasorum Coronary vessel Cardiology Female Endothelium Vascular medicine.symptom Tomography X-Ray Computed Cardiology and Cardiovascular Medicine business |
| Zdroj: | Cardiovascular Research. 51:762-766 |
| ISSN: | 0008-6363 |
| DOI: | 10.1016/s0008-6363(01)00347-9 |
| Popis: | Objective: Experimental hypercholesterolemia is associated with vasa vasorum neovascularization, unknown to occur before or after initial lesion formation. Thus, this study was performed to determine the temporal course of neovascularization of coronary vasa vasorum in relation to endothelial dysfunction, a hallmark of early atherosclerosis. Methods: Female domestic pigs were fed a normal diet (Group 1), a hypercholesterolemic diet for 2 and 4 weeks (Group 2), or a hypercholesterolemic diet for 6 and 12 weeks (Group 3). In vitro analysis of relaxation response to bradykinin served as an index for epicardial endothelial function. Spatial pattern and density of coronary vasa vasorum were assessed by three-dimensional microscopic computed tomography. Results: Relaxation response of coronary arteries to bradykinin was normal in both Group 1 (93±6%) and Group 2 (89±7%) but impaired in Group 3 (71±11%; P |
| Databáze: | OpenAIRE |
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