Hematopoietic stem progenitor cells prevent chronic stress-induced lymphocyte apoptosis
| Autor: | Mohamed Elgazzar, Nausheen Siddiqui, Deling Yin, Haiju Zhang, Hui Li, Yu Zhou, Yi Caudle |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male medicine.medical_treatment Lymphocyte Immunology Apoptosis Hematopoietic stem cell transplantation Biology Article 03 medical and health sciences Mice 0302 clinical medicine Immune system medicine Immunology and Allergy Animals Chronic stress Lymphocytes Progenitor cell Cells Cultured Mice Inbred BALB C Hematopoietic Stem Cell Transplantation Hematopoietic Stem Cells Haematopoiesis 030104 developmental biology medicine.anatomical_structure Neurology Neurology (clinical) 030217 neurology & neurosurgery Stress Psychological Hormone |
| Popis: | Physical or psychological chronic stress can suppress the immune system. However, the mechanisms remain to be elucidated. We investigated the effect of hematopoietic stem-progenitor cells (HSPCs) on chronic stress-induced the alterations of immune responses. We demonstrate that HSPCs prevents stress-induced lymphocyte apoptosis. Moreover, we also demonstrate that the protective effect of HSPCs on stress-induced lymphocyte reduction exerts by steroid hormones. Furthermore, we reveal that chronic stress-induced T cell-mediated immune responses contributes to the protective effect of HSPCs. These results indicate that HPSCs might offer a novel therapeutic strategy against the deleterious effects of chronic stress on the immune system. |
| Databáze: | OpenAIRE |
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