Angiotensin receptors in the kidney and vasculature in hypertension and kidney disease
| Autor: | Thien A. Hoang, Ritika Revoori, Fitra Rianto, Matthew A. Sparks |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Angiotensin receptor 030209 endocrinology & metabolism Blood Pressure Biochemistry Receptor Angiotensin Type 2 Receptor Angiotensin Type 1 Kidney Tubules Proximal Renin-Angiotensin System 03 medical and health sciences Mice 0302 clinical medicine Endocrinology Diabetes mellitus Renin–angiotensin system medicine Animals Humans Renal Insufficiency Chronic Receptor Molecular Biology Mice Knockout Kidney business.industry Angiotensin II Water-Electrolyte Balance medicine.disease Peptide Fragments 030104 developmental biology medicine.anatomical_structure Blood pressure Gene Expression Regulation Pathophysiology of hypertension Hypertension Cancer research Angiotensin-Converting Enzyme 2 Angiotensin I business Kidney disease Signal Transduction |
| Zdroj: | Molecular and cellular endocrinology. 529 |
| ISSN: | 1872-8057 |
| Popis: | Kidney disease, blood pressure determination, hypertension pathogenesis, and the renin-angiotensin system (RAS) are inextricably linked. Hence, understanding the RAS is pivotal to unraveling the pathophysiology of hypertension and the determinants to maintaining normal blood pressure. The RAS has been the subject of intense investigation for over a century. Moreover, medications that block the RAS are mainstay therapies in clinical medicine and have been shown to reduce morbidity and mortality in patients with diabetes, cardiovascular, and kidney diseases. The main effector peptide of the RAS is the interaction of the octapeptide- Ang II with its receptor. The type 1 angiotensin receptor (AT1R) is the effector receptor for Ang II. These G protein-coupled receptors (GPCRs) are ubiquitously expressed in a variety of cell lineages and tissues relevant to cardiovascular disease throughout the body. The advent of cell specific deletion of genes using Cre LoxP technology in mice has allowed for the identification of discreet actions of AT1Rs in blood pressure control and kidney disease. The kidney is one of the major targets of the RAS, which is responsible in maintaining fluid, electrolyte balance, and blood pressure. In this review we will discuss the role of AT1Rs in the kidney, vasculature, and immune cells and address their effects on hypertension and kidney disease. |
| Databáze: | OpenAIRE |
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