Image-guided radiofrequency ablation (RFA) of spinal tumors
| Autor: | Dietrich H.W. Groenemeyer, Athour Gevargez |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Male
medicine.medical_specialty Percutaneous Radiofrequency ablation medicine.medical_treatment Radiography Interventional Statistics Nonparametric law.invention law Humans Medicine Fluoroscopy Radiology Nuclear Medicine and imaging Rachis Aged Pain Measurement Retrospective Studies Aged 80 and over Spinal Neoplasms medicine.diagnostic_test business.industry General Medicine Middle Aged Ablation Surgery Radiation therapy Catheter Treatment Outcome Tumor progression Catheter Ablation Disease Progression Female Radiology business |
| Zdroj: | European Journal of Radiology. 65:246-252 |
| ISSN: | 0720-048X |
| DOI: | 10.1016/j.ejrad.2007.03.026 |
| Popis: | Purpose To evaluate retrospectively the efficacy and safety of radiofrequency ablation (RFA) in patients with spinal tumors. Materials and methods Forty-one patients (25 men, 16 women; age range, 46–82 years) with nonresectable primary or secondary tumor involvement of the spine unresponsive to chemo- and radiotherapy received RFA treatment. Two radiofrequency ablation systems, one with a cool-tip electrode and one with an expandable electrode catheter, were used. Both systems work impedance controlled with a power output of 150– 200 W. Each coagulation cycle lasted 12–15 min depending on tumor impedance. Several single RFA cycles of 15 min each were used for overlapping RFAs in tumors with diameters of more than 3 cm. Temperature was kept between 50 °C and 120 °C and was chosen according to spinal cord distance and patient heat tolerance during the ablation. Multi-slice computed tomography (CT) combined with C-arm fluoroscopy guided the intervention. Efficacy outcomes were assessed after about 6 weeks, 6 months, and more than 6 months using standardized questionnaires and indices regarding tumor pain, pain disability, functional activities, quality of life, neurological status, and tumor progression. Results RFA significantly reduced tumor-induced pain within 6 weeks, improved daily activities, and maintained quality of life. Mean time to tumor progression was 730 ± 54 days (Kaplan–Meier estimate). No RFA-associated complications were reported. Conclusion RFA of primary and secondary spinal tumors, which were unresponsive to chemo- and radiotherapy and prone to progression, is a safe, resource-saving, and highly effective percutaneous technique in patients with nonresectable spinal tumors. |
| Databáze: | OpenAIRE |
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