Temporal dynamics of Arc/Arg3.1 expression in the dorsal striatum during acquisition and consolidation of a motor skill in mice
| Autor: | Wan-Kun Gong, Zhi-Li Huang, Lu Wang, Lan-Fang Yu, Jian Ni |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
Dorsum Cognitive Neuroscience education Nerve Tissue Proteins Experimental and Cognitive Psychology Striatum Biology Globus Pallidus 050105 experimental psychology 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine Neural Pathways Animals Learning 0501 psychology and cognitive sciences Motor skill Memory Consolidation Neurons Arc (protein) Consolidation (soil) 05 social sciences Arc arg3 1 Motor Skill Consolidation Mice Inbred C57BL Neostriatum Substantia Nigra Cytoskeletal Proteins nervous system Motor Skills Motor learning Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Neurobiology of Learning and Memory. 168:107156 |
| ISSN: | 1074-7427 |
| DOI: | 10.1016/j.nlm.2019.107156 |
| Popis: | Region- and pathway-specific plasticity within striatal circuits is critically involved in the acquisition and long-term retention of a new motor skill as it becomes automatized. However, the molecular substrates contributing to this plasticity remain unclear. Here, we examined the expression of the activity-regulated cytoskeleton-associated protein (Arc) in the associative or dorsomedial striatum (DMS) and the sensorimotor or dorsolateral striatum (DLS), as well as in striatonigral and striatopallidal neurons, during different skill learning phases in the accelerating rotarod task. We found that Arc was mainly expressed in the DMS during early motor learning and progressively increased in the DLS during gradual motor skill consolidation. Moreover, Arc was preferentially expressed in striatopallidal neurons early in training and gradually increased in striatonigral neurons later in training. These data demonstrate that in the dorsal striatum, the expression of Arc exhibits a region- and cell-specific transfer during the learning of a motor skill, suggesting a link between striatal Arc expression and motor skill learning in mice. |
| Databáze: | OpenAIRE |
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